A survey on phytochemical and bioactivity of plant extracts from Malaysian forest reserves

J. Nardiah Rizwana, Nazlina Ibrahim, A. R. Mohd Razehar, A. Z. Siti Noraziah, C. Y. Ling, S. A. Shariffah Muzaimah, A. H. Farina, Wan Yaacob Wan Ahmad, Ishak Ahmad, L. B. Din

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Methanolic extracts of leaves from plants collected from two different forest reserves, namely, Gunung Stong, Dabong, Kelantan and Ulu Muda, Kedah in Malaysia were subjected to a study in phytochemical constituents screen, toxicity to brine shrimp, cytotoxicity to normal cells and antiviral activity. All the plant extracts contain saponins except for Cyrtandra cf. anisophyllea. Goniothalamus macrophyllus contains alkaloids, steroids/triterpenes and saponins. All the tested extracts were not toxic to the brine shrimp. In the cytotoxicity assay, the CTC 50 values recorded for all the extracts ranged between 21.540 mg/L (Galearia fulva) to more than 1000 mg/L (Cinnamomum javanicum, Cryptocarya costata, Scaphochlamys biloba, Diospyros frutescens, Galearia maingayi and Urophyllum blumeanum). From the CTC 50 values, ten of the extracts were considered toxic to Vero cells. In the antiviral test carried out using 0.1 CTC 50 of the various extracts, results showed that antiviral activity is effective when the cells were treated with the extracts and inoculated with measles virus at the same time. From this study, it was postulated that the most effective route for the extracts in preventing the killing of Vero cells by (MV) was through inactivation of virus particle or prevention of viral entry into the cells.

Original languageEnglish
Pages (from-to)203-210
Number of pages8
JournalJournal of Medicinal Plants Research
Volume4
Issue number3
Publication statusPublished - 4 Feb 2010

Fingerprint

forest reserves
Plant Extracts
Phytochemicals
plant extracts
phytopharmaceuticals
Antiviral Agents
Artemia
Vero Cells
Poisons
Saponins
Cryptocarya
Goniothalamus
extracts
Cinnamomum
Diospyros
Triterpenes
Measles virus
Plant Leaves
Malaysia
saponins

Keywords

  • Antiviral activity
  • Cytotoxicity
  • Phytochemical constituent
  • Toxicity to brine shrimp

ASJC Scopus subject areas

  • Pharmacology
  • Complementary and alternative medicine
  • Drug Discovery
  • Plant Science
  • Pharmaceutical Science

Cite this

Nardiah Rizwana, J., Ibrahim, N., Mohd Razehar, A. R., Siti Noraziah, A. Z., Ling, C. Y., Shariffah Muzaimah, S. A., ... Din, L. B. (2010). A survey on phytochemical and bioactivity of plant extracts from Malaysian forest reserves. Journal of Medicinal Plants Research, 4(3), 203-210.

A survey on phytochemical and bioactivity of plant extracts from Malaysian forest reserves. / Nardiah Rizwana, J.; Ibrahim, Nazlina; Mohd Razehar, A. R.; Siti Noraziah, A. Z.; Ling, C. Y.; Shariffah Muzaimah, S. A.; Farina, A. H.; Wan Ahmad, Wan Yaacob; Ahmad, Ishak; Din, L. B.

In: Journal of Medicinal Plants Research, Vol. 4, No. 3, 04.02.2010, p. 203-210.

Research output: Contribution to journalArticle

Nardiah Rizwana, J, Ibrahim, N, Mohd Razehar, AR, Siti Noraziah, AZ, Ling, CY, Shariffah Muzaimah, SA, Farina, AH, Wan Ahmad, WY, Ahmad, I & Din, LB 2010, 'A survey on phytochemical and bioactivity of plant extracts from Malaysian forest reserves', Journal of Medicinal Plants Research, vol. 4, no. 3, pp. 203-210.
Nardiah Rizwana J, Ibrahim N, Mohd Razehar AR, Siti Noraziah AZ, Ling CY, Shariffah Muzaimah SA et al. A survey on phytochemical and bioactivity of plant extracts from Malaysian forest reserves. Journal of Medicinal Plants Research. 2010 Feb 4;4(3):203-210.
Nardiah Rizwana, J. ; Ibrahim, Nazlina ; Mohd Razehar, A. R. ; Siti Noraziah, A. Z. ; Ling, C. Y. ; Shariffah Muzaimah, S. A. ; Farina, A. H. ; Wan Ahmad, Wan Yaacob ; Ahmad, Ishak ; Din, L. B. / A survey on phytochemical and bioactivity of plant extracts from Malaysian forest reserves. In: Journal of Medicinal Plants Research. 2010 ; Vol. 4, No. 3. pp. 203-210.
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