A study protocol: Spinal morphology, physical performance, quality of life and biochemical markers in adults at risk of osteoporotic fractures

S. K. Chua, Devinder Kaur Ajit Singh, B. S. Rajaratnam, Sabarul Afian Mokhtar, R. Sridharan, Gan Kok Beng, Chin Kok Yong, R. Y.W. Lee

Research output: Contribution to journalArticle

Abstract

Older adults are at risk of osteoporotic fractures. Osteoporotic vertebral fractures are associated with a reduced cross-sectional area and muscle strength of the back extensor muscles, increased intramuscular fat infiltration and thoracic and lumbar curvature alterations. This study proposed a protocol to examine in more detail the contributions of altered spinal morphological, physical performance and biochemical markers to the risk of developing osteoporotic vertebral fractures. In this cross-sectional study, we plan to recruit 100 adults aged 50 years and above from an orthopaedic clinic, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia. The fracture prediction tool (FRAX) will be used to categorise high and low risk groups. Back muscle strength will be quantified using a load cell system. Thoracolumbar curvatures will be examined using an electromagnetic tracking system and intramuscular fat infiltration in the lumbar muscles will be measured using Magnetic Resonance Imaging. The Short Physical Performance Battery and JAMA dynamometer will quantify physical performance and the European Quality of Life Questionnaire will be used to assess self-perceived quality of life. Biochemical markers of serum C terminal telopeptide and N terminal propeptide of type I procollagen will be assessed using an enzyme-linked immunosorbent assays kit. A spine-specific model using regression analysis will be developed to predict osteoporotic vertebral fractures using the measured parameters in the present study.

Original languageEnglish
Pages (from-to)1123-1134
Number of pages12
JournalPertanika Journal of Science and Technology
Volume25
Issue number4
Publication statusPublished - 1 Oct 2017

Fingerprint

muscle strength
Osteoporotic Fractures
intramuscular fat
quality of life
biomarkers
Biomarkers
Quality of Life
Back Muscles
Muscle
dynamometers
muscle
muscles
risk groups
orthopedics
Muscle Strength
chest
magnetic resonance imaging
cross-sectional studies
Malaysia
Oils and fats

Keywords

  • Biochemical markers
  • Intramuscular fat infiltration
  • Osteoporotic fracture
  • Physical performance
  • Quality of life
  • Spinal morphology

ASJC Scopus subject areas

  • Computer Science(all)
  • Chemical Engineering(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{ebc2783f6b0741dca1c6c09c33c99881,
title = "A study protocol: Spinal morphology, physical performance, quality of life and biochemical markers in adults at risk of osteoporotic fractures",
abstract = "Older adults are at risk of osteoporotic fractures. Osteoporotic vertebral fractures are associated with a reduced cross-sectional area and muscle strength of the back extensor muscles, increased intramuscular fat infiltration and thoracic and lumbar curvature alterations. This study proposed a protocol to examine in more detail the contributions of altered spinal morphological, physical performance and biochemical markers to the risk of developing osteoporotic vertebral fractures. In this cross-sectional study, we plan to recruit 100 adults aged 50 years and above from an orthopaedic clinic, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia. The fracture prediction tool (FRAX) will be used to categorise high and low risk groups. Back muscle strength will be quantified using a load cell system. Thoracolumbar curvatures will be examined using an electromagnetic tracking system and intramuscular fat infiltration in the lumbar muscles will be measured using Magnetic Resonance Imaging. The Short Physical Performance Battery and JAMA dynamometer will quantify physical performance and the European Quality of Life Questionnaire will be used to assess self-perceived quality of life. Biochemical markers of serum C terminal telopeptide and N terminal propeptide of type I procollagen will be assessed using an enzyme-linked immunosorbent assays kit. A spine-specific model using regression analysis will be developed to predict osteoporotic vertebral fractures using the measured parameters in the present study.",
keywords = "Biochemical markers, Intramuscular fat infiltration, Osteoporotic fracture, Physical performance, Quality of life, Spinal morphology",
author = "Chua, {S. K.} and {Ajit Singh}, {Devinder Kaur} and Rajaratnam, {B. S.} and Mokhtar, {Sabarul Afian} and R. Sridharan and {Kok Beng}, Gan and {Kok Yong}, Chin and Lee, {R. Y.W.}",
year = "2017",
month = "10",
day = "1",
language = "English",
volume = "25",
pages = "1123--1134",
journal = "Pertanika Journal of Science and Technology",
issn = "0128-7680",
publisher = "Universiti Putra Malaysia",
number = "4",

}

TY - JOUR

T1 - A study protocol

T2 - Spinal morphology, physical performance, quality of life and biochemical markers in adults at risk of osteoporotic fractures

AU - Chua, S. K.

AU - Ajit Singh, Devinder Kaur

AU - Rajaratnam, B. S.

AU - Mokhtar, Sabarul Afian

AU - Sridharan, R.

AU - Kok Beng, Gan

AU - Kok Yong, Chin

AU - Lee, R. Y.W.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Older adults are at risk of osteoporotic fractures. Osteoporotic vertebral fractures are associated with a reduced cross-sectional area and muscle strength of the back extensor muscles, increased intramuscular fat infiltration and thoracic and lumbar curvature alterations. This study proposed a protocol to examine in more detail the contributions of altered spinal morphological, physical performance and biochemical markers to the risk of developing osteoporotic vertebral fractures. In this cross-sectional study, we plan to recruit 100 adults aged 50 years and above from an orthopaedic clinic, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia. The fracture prediction tool (FRAX) will be used to categorise high and low risk groups. Back muscle strength will be quantified using a load cell system. Thoracolumbar curvatures will be examined using an electromagnetic tracking system and intramuscular fat infiltration in the lumbar muscles will be measured using Magnetic Resonance Imaging. The Short Physical Performance Battery and JAMA dynamometer will quantify physical performance and the European Quality of Life Questionnaire will be used to assess self-perceived quality of life. Biochemical markers of serum C terminal telopeptide and N terminal propeptide of type I procollagen will be assessed using an enzyme-linked immunosorbent assays kit. A spine-specific model using regression analysis will be developed to predict osteoporotic vertebral fractures using the measured parameters in the present study.

AB - Older adults are at risk of osteoporotic fractures. Osteoporotic vertebral fractures are associated with a reduced cross-sectional area and muscle strength of the back extensor muscles, increased intramuscular fat infiltration and thoracic and lumbar curvature alterations. This study proposed a protocol to examine in more detail the contributions of altered spinal morphological, physical performance and biochemical markers to the risk of developing osteoporotic vertebral fractures. In this cross-sectional study, we plan to recruit 100 adults aged 50 years and above from an orthopaedic clinic, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia. The fracture prediction tool (FRAX) will be used to categorise high and low risk groups. Back muscle strength will be quantified using a load cell system. Thoracolumbar curvatures will be examined using an electromagnetic tracking system and intramuscular fat infiltration in the lumbar muscles will be measured using Magnetic Resonance Imaging. The Short Physical Performance Battery and JAMA dynamometer will quantify physical performance and the European Quality of Life Questionnaire will be used to assess self-perceived quality of life. Biochemical markers of serum C terminal telopeptide and N terminal propeptide of type I procollagen will be assessed using an enzyme-linked immunosorbent assays kit. A spine-specific model using regression analysis will be developed to predict osteoporotic vertebral fractures using the measured parameters in the present study.

KW - Biochemical markers

KW - Intramuscular fat infiltration

KW - Osteoporotic fracture

KW - Physical performance

KW - Quality of life

KW - Spinal morphology

UR - http://www.scopus.com/inward/record.url?scp=85049218763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049218763&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85049218763

VL - 25

SP - 1123

EP - 1134

JO - Pertanika Journal of Science and Technology

JF - Pertanika Journal of Science and Technology

SN - 0128-7680

IS - 4

ER -