A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

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Abstract

Background: α-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, 13C and 1H NMR as well as UV-vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH.Result: The DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6.Conclusion: This research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template.

Original languageEnglish
Article number85
JournalChemistry Central Journal
Volume7
Issue number1
DOIs
Publication statusPublished - 16 May 2013

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Column chromatography
Silica Gel
Fruits
Ultraviolet spectroscopy
Nuclear magnetic resonance spectroscopy
Methanol
mangostin
Infrared radiation
Crystals
poly-N-isopropylacrylamide

Keywords

  • α-Mangostin
  • Dynamic light scattering (DLS)
  • Microgel
  • Transmission electron microscope (TEM)

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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title = "A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems",
abstract = "Background: α-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, 13C and 1H NMR as well as UV-vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH.Result: The DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6.Conclusion: This research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template.",
keywords = "α-Mangostin, Dynamic light scattering (DLS), Microgel, Transmission electron microscope (TEM)",
author = "Madihah Ahmad and {Mohd. Yamin}, Bohari and {Mat Lazim}, {Mohamad Azwani Shah}",
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language = "English",
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T1 - A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

AU - Ahmad, Madihah

AU - Mohd. Yamin, Bohari

AU - Mat Lazim, Mohamad Azwani Shah

PY - 2013/5/16

Y1 - 2013/5/16

N2 - Background: α-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, 13C and 1H NMR as well as UV-vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH.Result: The DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6.Conclusion: This research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template.

AB - Background: α-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, 13C and 1H NMR as well as UV-vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH.Result: The DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6.Conclusion: This research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template.

KW - α-Mangostin

KW - Dynamic light scattering (DLS)

KW - Microgel

KW - Transmission electron microscope (TEM)

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