A review on the effects of testosterone supplementation in hypogonadal men with cognitive impairment

Nur Vaizura Mohamad, Ima Nirwana Soelaiman, Chin Kok Yong

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Cognitive function and testosterone level of men decline concurrently with age. Low testosterone levels are associated with higher risk of Alzheimer’s disease and mild cognitive impairment in men. There are continuous debates on whether this relationship is casual. This paper aims to summarize the current evidence on the association between testosterone level and cognitive function in elderly men. The presence of testosterone, androgen receptor and its responsive genes indicates that testosterone has biological functions in the central nervous system. The ability of the body to convert testosterone into estrogen suggests that part of the actions of testosterone could be mediated by estrogen. Observational studies generally showed that low endogenous testosterone levels were associated with poor cognitive performance in healthy elderly men. Testosterone substitution exerted positive effects on certain cognitive domains in normal and hypogonadal elderly men. In conclusion, testosterone may influence cognitive function in elderly men and its substitution may be considered in men with cognitive impairment and testosterone deficiency.

Original languageEnglish
Pages (from-to)898-906
Number of pages9
JournalCurrent Drug Targets
Volume19
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Testosterone
Cognition
Androgen Receptors
Estrogens
Cognitive Dysfunction
Substitution reactions
Aptitude
Neurology
Observational Studies
Alzheimer Disease
Central Nervous System
Genes
Association reactions

Keywords

  • Aging
  • Alzheimer
  • Brain
  • Cognitive ability
  • Hypogonadism
  • Testosterone

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

A review on the effects of testosterone supplementation in hypogonadal men with cognitive impairment. / Mohamad, Nur Vaizura; Soelaiman, Ima Nirwana; Kok Yong, Chin.

In: Current Drug Targets, Vol. 19, No. 8, 01.01.2018, p. 898-906.

Research output: Contribution to journalReview article

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