A review on the antinociceptive effects of mitragyna speciosa and its derivatives on animal model

Chin Kok Yong, Wun Fui Mark-Lee

Research output: Contribution to journalReview article

Abstract

Mitragyna speciosa is a tropical plant with narcotic effects. The antinociceptive effects of its crude extracts, bioactive compounds and structurally modified derivatives have been examined in rodent models. This review aims to summarize the evidence on the antinociceptive effects of M. speciosa and its derivatives and explore whether they can offer an alternative to morphine in pain management. Methanolic and alkaloid extracts of M. speciosa were shown to attenuate the nociceptive response in rodents. Mitragynine and 7-hydroxymitragynine offered better antinociceptive effects than crude extracts. Structurally modified derivatives of 7-hydroxymitragynine, such as MGM-9, MGM-15, MGM-16, demonstrated superior antinociceptive effects compared to morphine. M. speciosa and its derivatives mainly act on the opioid receptor, but receptor subtypes specificity differs between each compound. The tolerance and adverse side effects of M. speciosa and its derivatives are similar with morphine. The affinity of MGM-9 on kappa-opioid receptor could potentially limit the effects of drug dependence. In conclusion, M speciosa derivatives can offer alternatives to morphine in controlling chronic pain. Structural modification of mitragynine and 7-hydroxymitragynine can generate compounds with higher potency and lesser side-effects. Human clinical trials are required to validate the use of these compounds in clinical setting.

Original languageEnglish
Pages (from-to)1359-1365
Number of pages7
JournalCurrent Drug Targets
Volume19
Issue number12
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Mitragyna
Morphine
Animals
Animal Models
Derivatives
Complex Mixtures
Rodentia
kappa Opioid Receptor
Narcotics
Opioid Receptors
Pain Management
Alkaloids
Chronic Pain
Substance-Related Disorders
Clinical Trials
7-hydroxymitragynine

Keywords

  • Analgesia
  • Ketum
  • Morphine
  • Narcotic
  • Nociception
  • Opioid
  • Pain

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

A review on the antinociceptive effects of mitragyna speciosa and its derivatives on animal model. / Kok Yong, Chin; Mark-Lee, Wun Fui.

In: Current Drug Targets, Vol. 19, No. 12, 01.01.2018, p. 1359-1365.

Research output: Contribution to journalReview article

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