A review on effect of genetic features on treatment responses in acute myeloid leukemia

Emilia Apidi, Wan Rohani Wan Taib, Rosline Hassan, Nurul Syakima Ab Mutalib, Imilia Ismail

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background: Acute myeloid leukemia is a hematological disorder distinguished by clonal expansion of undifferentiated myeloid precursors leading to impaired haematopoiesis. The presence of various types of genetic mutations and chromosomal abnormalities in AML are among the critical factors affecting clinical outcomes and response to induction and post-remission treatment. Aim: In this review, we collate the findings from previous literatures regarding the effects of cytogenetics and molecular mutations on the response to induction (either lower or intensified) treatment. In addition to the gene mutations in AML that influence the clinical decisions for post-remission treatment, we also focus on the prognostic significance of several members of inhibitor of apoptosis protein (IAP) family as well as their endogenous inhibitor, Smac/DIABLO that have shown great promise as a marker in predicting response to AML treatment regimen from the associated publications. Conclusion: Incorporating this knowledge into the clinical settings is important enough in order to improve the disease outcome and clinical management of patients with AML.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalMeta Gene
Volume18
DOIs
Publication statusPublished - 1 Dec 2018
Externally publishedYes

Fingerprint

Acute Myeloid Leukemia
Mutation
Inhibitor of Apoptosis Proteins
Remission Induction
Hematopoiesis
Therapeutics
Cytogenetics
Chromosome Aberrations
Publications
Genes

Keywords

  • Acute myeloid leukemia
  • Cytogenetics
  • Molecular mutations
  • Treatment response

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A review on effect of genetic features on treatment responses in acute myeloid leukemia. / Apidi, Emilia; Wan Taib, Wan Rohani; Hassan, Rosline; Ab Mutalib, Nurul Syakima; Ismail, Imilia.

In: Meta Gene, Vol. 18, 01.12.2018, p. 31-38.

Research output: Contribution to journalReview article

Apidi, Emilia ; Wan Taib, Wan Rohani ; Hassan, Rosline ; Ab Mutalib, Nurul Syakima ; Ismail, Imilia. / A review on effect of genetic features on treatment responses in acute myeloid leukemia. In: Meta Gene. 2018 ; Vol. 18. pp. 31-38.
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