A review of flavonoid quercetin

Metabolism, Bioactivity and antioxidant properties

Nadia Salem Alrawaiq, Azman Abdullah

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Flavonoids belong to a category of polyphenolic compounds that are produced exclusively in plants. These compounds are able to bring about various biological and pharmacological activities in animal cells. It is generally believed that most mammals need to consume polyphenols from plants due to their antioxidant properties in order to stay healthy. The antioxidants are essential for protecting the cells from undergoing chemical damage due to oxidation. Many compounds are known to have both antioxidant and pro-oxidant properties. The pro-oxidant properties can either be favourable or detrimental to biological systems and can affect the progress of chronic diseases in human beings. Quercetin, the most plentiful flavonoid, acts as both an antioxidant and a pro-oxidant. Currently, there is no reliable method for maintaining a balance between these two activities in the whole organism. Therefore, this review focuses onMetabolism, bioactivity and both the antioxidant and pro-oxidant effects of flavonoids.

Original languageEnglish
Pages (from-to)933-941
Number of pages9
JournalInternational Journal of PharmTech Research
Volume6
Issue number3
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Quercetin
Flavonoids
Antioxidants
Reactive Oxygen Species
Polyphenols
Mammals
Chronic Disease
Pharmacology

Keywords

  • Antioxidant
  • Nrf2
  • Phase II enzyme
  • Quercetin

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

A review of flavonoid quercetin : Metabolism, Bioactivity and antioxidant properties. / Salem Alrawaiq, Nadia; Abdullah, Azman.

In: International Journal of PharmTech Research, Vol. 6, No. 3, 2014, p. 933-941.

Research output: Contribution to journalArticle

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