A review of antioxidant polyphenol curcumin and its role in detoxification

Nadia Salem Alrawaiq, Azman Abdullah

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Curcumin (diferuloymethane), a yellow colouring agent present in the rhizome of Curcuma longa Linn (Zingiberaceae), has been reported to possess anti-inflammatory, antioxidant and anticarcinogenic activities. Despite such significant anti-tumor efficacies and bio-safety profiles of curcumin, its poor systemic bioavailability originating from sub-optimal absorption, rapid metabolism and fast systemic elimination, is turning out to be one of the major impeding factors retarding its clinical success. Curcumin exerts its chemoprotective and chemopreventive effects via multiple mechanisms. It has been reported to induce expression of the antioxidant enzymes in various cell lines. Curcumin significantly increased expression of Nrf2 as well as phase II detoxifying and antioxidant enzymes. The redox-sensitive transcription factor, nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2) plays a key role in regulating induction of phase II detoxifying or antioxidant enzymes. Thus, activation of Nrf2 is considered to be an important molecular target of many chemopreventive and chemoprotective agents. This review summarizes the molecular basis of chemoprevention and cytoprotection afforded by curcumin with emphasis on its ability to modulate Nrf2-mediated cellular events. In this review, we describe both antioxidant activity and effects of curcumin on biotransformation enzymes involved in carcinogen metabolism.

Original languageEnglish
Pages (from-to)280-289
Number of pages10
JournalInternational Journal of PharmTech Research
Volume6
Issue number1
Publication statusPublished - Jan 2014

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Curcumin
Polyphenols
Antioxidants
Enzymes
NF-E2 Transcription Factor
Zingiberaceae
Curcuma
Rhizome
Cytoprotection
Chemoprevention
Biotransformation
Carcinogens
Biological Availability
Oxidation-Reduction
Anti-Inflammatory Agents
Coloring Agents
Safety
Cell Line
Neoplasms

Keywords

  • Curcumin
  • Metabolism
  • Nrf2
  • Phase II detoxifying enzymes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

A review of antioxidant polyphenol curcumin and its role in detoxification. / Alrawaiq, Nadia Salem; Abdullah, Azman.

In: International Journal of PharmTech Research, Vol. 6, No. 1, 01.2014, p. 280-289.

Research output: Contribution to journalArticle

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