A retrospective cross-sectional study: Expression of p53 protein in papillary thyroid carcinoma and its prognostic implications

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Abstract

Introduction: Immunohistochemical detection of p53 protein has recently come to light as one of the significant and independent prognostic indicators in papillary thyroid carcinoma. Previous studies have conflicting results and to date, the association is still a matter of controversy. Our study is to examine the significance and prognostic values of p53 protein overexpression in papillary thyroid carcinoma patients among Malaysia population, and provide extra evidence on significance of p53 protein in papillary thyroid carcinoma prognostification. Methods: This is a single centre, retrospective cross-sectional study of association between p53 protein expression as a risk factor in patient with papillary thyroid carcinoma with its clinicopathological features (tumour size, extrathyroid invasion, lymph node metastasis, and distant metastasis) as the outcomes. Expression of p53 was regarded as positive if more than 10% of cells were stained. Positive slides were further divided to weak (<40%), moderate (40%-70%), and strong (>70%). Results: Total 46 patients were recruited for the study. 34 (73.9%) cases showed positivity for p53 protein over-expression and 12 (26.1%) were negative. The average tumour size was 34mm for p53 positive cases and 33mm for p53 negative cases. Extrathyroidal extension was present in 15 (44.1%) of p53 positive cases and four (33.3%) of p53 negative cases. There were eight (23.5%) p53 positive cases and five (41.7%) p53 negative cases showed lymphovascular invasion. Lymph node metastasis was present in 21 (61.8%) p53 positive cases and eight (66.7%) p53 negative cases. All parameters (mean tumor size, extrathyroidal invasion, lymphovascular invasion, lymph node metastasis and distant metastasis) and the stain intensity revealed no significant correlation with p53 protein over-expression in statistical analysis. Conclusion: As a conclusion, our study showed that there was no correlation between p53 protein over-expression and the clinicopathological features in papillary thyroid carcinoma.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalSurgical Chronicles
Volume23
Issue number1
Publication statusPublished - 1 Jan 2018

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Cross-Sectional Studies
Neoplasm Metastasis
Proteins
Lymph Nodes
Neoplasms
Malaysia
Papillary Thyroid cancer
Coloring Agents
Population

Keywords

  • Clinicopathology significance
  • Immunohistochemical stain
  • P53 protein expression
  • Papillary thyroid carcinoma
  • Prognostic implication

ASJC Scopus subject areas

  • Surgery

Cite this

@article{80ad994d5fb74425833b81a481cd0cfb,
title = "A retrospective cross-sectional study: Expression of p53 protein in papillary thyroid carcinoma and its prognostic implications",
abstract = "Introduction: Immunohistochemical detection of p53 protein has recently come to light as one of the significant and independent prognostic indicators in papillary thyroid carcinoma. Previous studies have conflicting results and to date, the association is still a matter of controversy. Our study is to examine the significance and prognostic values of p53 protein overexpression in papillary thyroid carcinoma patients among Malaysia population, and provide extra evidence on significance of p53 protein in papillary thyroid carcinoma prognostification. Methods: This is a single centre, retrospective cross-sectional study of association between p53 protein expression as a risk factor in patient with papillary thyroid carcinoma with its clinicopathological features (tumour size, extrathyroid invasion, lymph node metastasis, and distant metastasis) as the outcomes. Expression of p53 was regarded as positive if more than 10{\%} of cells were stained. Positive slides were further divided to weak (<40{\%}), moderate (40{\%}-70{\%}), and strong (>70{\%}). Results: Total 46 patients were recruited for the study. 34 (73.9{\%}) cases showed positivity for p53 protein over-expression and 12 (26.1{\%}) were negative. The average tumour size was 34mm for p53 positive cases and 33mm for p53 negative cases. Extrathyroidal extension was present in 15 (44.1{\%}) of p53 positive cases and four (33.3{\%}) of p53 negative cases. There were eight (23.5{\%}) p53 positive cases and five (41.7{\%}) p53 negative cases showed lymphovascular invasion. Lymph node metastasis was present in 21 (61.8{\%}) p53 positive cases and eight (66.7{\%}) p53 negative cases. All parameters (mean tumor size, extrathyroidal invasion, lymphovascular invasion, lymph node metastasis and distant metastasis) and the stain intensity revealed no significant correlation with p53 protein over-expression in statistical analysis. Conclusion: As a conclusion, our study showed that there was no correlation between p53 protein over-expression and the clinicopathological features in papillary thyroid carcinoma.",
keywords = "Clinicopathology significance, Immunohistochemical stain, P53 protein expression, Papillary thyroid carcinoma, Prognostic implication",
author = "Ng, {C. B.} and {Nur Maya Sabrina}, {T. L.} and {Md Pauzi}, {Suria Hayati} and {Md Isa}, Nurismah and {Abdullah Suhaimi}, {Shahrun Niza}",
year = "2018",
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day = "1",
language = "English",
volume = "23",
pages = "10--14",
journal = "Surgical Chronicles",
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publisher = "Surgical Society of Northern Greece",
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T1 - A retrospective cross-sectional study

T2 - Expression of p53 protein in papillary thyroid carcinoma and its prognostic implications

AU - Ng, C. B.

AU - Nur Maya Sabrina, T. L.

AU - Md Pauzi, Suria Hayati

AU - Md Isa, Nurismah

AU - Abdullah Suhaimi, Shahrun Niza

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Immunohistochemical detection of p53 protein has recently come to light as one of the significant and independent prognostic indicators in papillary thyroid carcinoma. Previous studies have conflicting results and to date, the association is still a matter of controversy. Our study is to examine the significance and prognostic values of p53 protein overexpression in papillary thyroid carcinoma patients among Malaysia population, and provide extra evidence on significance of p53 protein in papillary thyroid carcinoma prognostification. Methods: This is a single centre, retrospective cross-sectional study of association between p53 protein expression as a risk factor in patient with papillary thyroid carcinoma with its clinicopathological features (tumour size, extrathyroid invasion, lymph node metastasis, and distant metastasis) as the outcomes. Expression of p53 was regarded as positive if more than 10% of cells were stained. Positive slides were further divided to weak (<40%), moderate (40%-70%), and strong (>70%). Results: Total 46 patients were recruited for the study. 34 (73.9%) cases showed positivity for p53 protein over-expression and 12 (26.1%) were negative. The average tumour size was 34mm for p53 positive cases and 33mm for p53 negative cases. Extrathyroidal extension was present in 15 (44.1%) of p53 positive cases and four (33.3%) of p53 negative cases. There were eight (23.5%) p53 positive cases and five (41.7%) p53 negative cases showed lymphovascular invasion. Lymph node metastasis was present in 21 (61.8%) p53 positive cases and eight (66.7%) p53 negative cases. All parameters (mean tumor size, extrathyroidal invasion, lymphovascular invasion, lymph node metastasis and distant metastasis) and the stain intensity revealed no significant correlation with p53 protein over-expression in statistical analysis. Conclusion: As a conclusion, our study showed that there was no correlation between p53 protein over-expression and the clinicopathological features in papillary thyroid carcinoma.

AB - Introduction: Immunohistochemical detection of p53 protein has recently come to light as one of the significant and independent prognostic indicators in papillary thyroid carcinoma. Previous studies have conflicting results and to date, the association is still a matter of controversy. Our study is to examine the significance and prognostic values of p53 protein overexpression in papillary thyroid carcinoma patients among Malaysia population, and provide extra evidence on significance of p53 protein in papillary thyroid carcinoma prognostification. Methods: This is a single centre, retrospective cross-sectional study of association between p53 protein expression as a risk factor in patient with papillary thyroid carcinoma with its clinicopathological features (tumour size, extrathyroid invasion, lymph node metastasis, and distant metastasis) as the outcomes. Expression of p53 was regarded as positive if more than 10% of cells were stained. Positive slides were further divided to weak (<40%), moderate (40%-70%), and strong (>70%). Results: Total 46 patients were recruited for the study. 34 (73.9%) cases showed positivity for p53 protein over-expression and 12 (26.1%) were negative. The average tumour size was 34mm for p53 positive cases and 33mm for p53 negative cases. Extrathyroidal extension was present in 15 (44.1%) of p53 positive cases and four (33.3%) of p53 negative cases. There were eight (23.5%) p53 positive cases and five (41.7%) p53 negative cases showed lymphovascular invasion. Lymph node metastasis was present in 21 (61.8%) p53 positive cases and eight (66.7%) p53 negative cases. All parameters (mean tumor size, extrathyroidal invasion, lymphovascular invasion, lymph node metastasis and distant metastasis) and the stain intensity revealed no significant correlation with p53 protein over-expression in statistical analysis. Conclusion: As a conclusion, our study showed that there was no correlation between p53 protein over-expression and the clinicopathological features in papillary thyroid carcinoma.

KW - Clinicopathology significance

KW - Immunohistochemical stain

KW - P53 protein expression

KW - Papillary thyroid carcinoma

KW - Prognostic implication

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