A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries

Takashi Nakano, Shingo Kato, Jianping Cao, Juying Zhou, Raden Susworo, Nana Supriana, Shinichiro Sato, Tatsuya Ohno, Hisao Suto, Yuzuru Nakamura, Chul Koo Cho, Fuad Ismail, Miriam J C Calaguas, Rey H. de los Reyes, Yaowalak Chansilpa, Kullathom Thephamongkhol, Nguyen Ba Duc, To Anh Dung, Hirohiko Tsujii

Research output: Contribution to journalArticle

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Abstract

Purpose: Radiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted. Materials and methods: Eleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50 Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28 Gy/4 fractions for HDR-ICBT and 30-40 Gy/1-2 fractions for LDR-ICBT. Results: Hundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32 Gy in the HDR group and 26-52.7 Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group. Conclusions: Although there were several problems with treatment compliance and patients' follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia.

Original languageEnglish
Pages (from-to)314-319
Number of pages6
JournalRadiotherapy and Oncology
Volume84
Issue number3
DOIs
Publication statusPublished - Sep 2007

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Brachytherapy
Uterine Cervical Neoplasms
Radiotherapy
Far East
Institutional Practice
Patient Compliance
Clinical Studies
Survival Rate
Economics
Therapeutics

Keywords

  • Cervical cancer
  • Developing country
  • East and south-east Asia
  • International clinical study
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Urology

Cite this

A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. / Nakano, Takashi; Kato, Shingo; Cao, Jianping; Zhou, Juying; Susworo, Raden; Supriana, Nana; Sato, Shinichiro; Ohno, Tatsuya; Suto, Hisao; Nakamura, Yuzuru; Cho, Chul Koo; Ismail, Fuad; Calaguas, Miriam J C; de los Reyes, Rey H.; Chansilpa, Yaowalak; Thephamongkhol, Kullathom; Duc, Nguyen Ba; Dung, To Anh; Tsujii, Hirohiko.

In: Radiotherapy and Oncology, Vol. 84, No. 3, 09.2007, p. 314-319.

Research output: Contribution to journalArticle

Nakano, T, Kato, S, Cao, J, Zhou, J, Susworo, R, Supriana, N, Sato, S, Ohno, T, Suto, H, Nakamura, Y, Cho, CK, Ismail, F, Calaguas, MJC, de los Reyes, RH, Chansilpa, Y, Thephamongkhol, K, Duc, NB, Dung, TA & Tsujii, H 2007, 'A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries', Radiotherapy and Oncology, vol. 84, no. 3, pp. 314-319. https://doi.org/10.1016/j.radonc.2007.05.012
Nakano, Takashi ; Kato, Shingo ; Cao, Jianping ; Zhou, Juying ; Susworo, Raden ; Supriana, Nana ; Sato, Shinichiro ; Ohno, Tatsuya ; Suto, Hisao ; Nakamura, Yuzuru ; Cho, Chul Koo ; Ismail, Fuad ; Calaguas, Miriam J C ; de los Reyes, Rey H. ; Chansilpa, Yaowalak ; Thephamongkhol, Kullathom ; Duc, Nguyen Ba ; Dung, To Anh ; Tsujii, Hirohiko. / A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. In: Radiotherapy and Oncology. 2007 ; Vol. 84, No. 3. pp. 314-319.
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AU - Nakano, Takashi

AU - Kato, Shingo

AU - Cao, Jianping

AU - Zhou, Juying

AU - Susworo, Raden

AU - Supriana, Nana

AU - Sato, Shinichiro

AU - Ohno, Tatsuya

AU - Suto, Hisao

AU - Nakamura, Yuzuru

AU - Cho, Chul Koo

AU - Ismail, Fuad

AU - Calaguas, Miriam J C

AU - de los Reyes, Rey H.

AU - Chansilpa, Yaowalak

AU - Thephamongkhol, Kullathom

AU - Duc, Nguyen Ba

AU - Dung, To Anh

AU - Tsujii, Hirohiko

PY - 2007/9

Y1 - 2007/9

N2 - Purpose: Radiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted. Materials and methods: Eleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50 Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28 Gy/4 fractions for HDR-ICBT and 30-40 Gy/1-2 fractions for LDR-ICBT. Results: Hundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32 Gy in the HDR group and 26-52.7 Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group. Conclusions: Although there were several problems with treatment compliance and patients' follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia.

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KW - International clinical study

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