A preliminary study on the prevalence of intestinal microsporidiosis in patients with and without gastrointestinal symptoms in Malaysia

Norhayati Moktar, `Azlin Muhammad @ Mohd Yasin, M. Hesham Al-Mekhlafi, Anisah Nordin, U. Nor Aini, M. S. Fatmah, A. R. Rozlida

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14 Citations (Scopus)

Abstract

An observational study was carried out to establish the existence of intestinal microsporidiosis among patients with and without gastrointestinal symptoms in Hospital Universiti Kebangsaan Malaysia, Malaysia. A total of 893 faecal specimens from hospitalized patients were examined for microsporidia using a modification of the usual Gram-chromotrope stain technique. One hundred and sixteen (13.0%) patients were positive for microsporidia: 84 (72.4%), 27 (23.3%) and 5 (4.3%) were low, moderate and high excreters of microsporidia spores, respectively. Of the 91 patients with available medical records, microsporidiosis was commonly observed in children aged 0-6 years (26.4%) and adults aged ≥31 years (57.2%). About one-third of this infection was observed in immunocompetent individuals. Among the immunosuppressive group, microsporidia were observed to be more prevalent in patients with haematological malignancy or a combination of malignancy and diabetes mellitus. About 74% of the patients who had microsporidia in their faeces had gastrointestinal symptoms, which could be related to infections or induced by immunosuppressive therapy. The role of microsporidia in causing gastrointestinal symptoms in this population is as yet unclear.

Original languageEnglish
Pages (from-to)1274-1278
Number of pages5
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume102
Issue number12
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Microsporidiosis
Microsporidia
Malaysia
Cross-Sectional Studies
Immunosuppressive Agents
Hematologic Neoplasms
Infection
Spores
Feces
Medical Records
Observational Studies
Diabetes Mellitus
Population

Keywords

  • Gastrointestinal diseases
  • Immunocompetence
  • Immunosuppressive agents
  • Malaysia
  • Microsporidia
  • Microsporidiosis

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

Cite this

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title = "A preliminary study on the prevalence of intestinal microsporidiosis in patients with and without gastrointestinal symptoms in Malaysia",
abstract = "An observational study was carried out to establish the existence of intestinal microsporidiosis among patients with and without gastrointestinal symptoms in Hospital Universiti Kebangsaan Malaysia, Malaysia. A total of 893 faecal specimens from hospitalized patients were examined for microsporidia using a modification of the usual Gram-chromotrope stain technique. One hundred and sixteen (13.0{\%}) patients were positive for microsporidia: 84 (72.4{\%}), 27 (23.3{\%}) and 5 (4.3{\%}) were low, moderate and high excreters of microsporidia spores, respectively. Of the 91 patients with available medical records, microsporidiosis was commonly observed in children aged 0-6 years (26.4{\%}) and adults aged ≥31 years (57.2{\%}). About one-third of this infection was observed in immunocompetent individuals. Among the immunosuppressive group, microsporidia were observed to be more prevalent in patients with haematological malignancy or a combination of malignancy and diabetes mellitus. About 74{\%} of the patients who had microsporidia in their faeces had gastrointestinal symptoms, which could be related to infections or induced by immunosuppressive therapy. The role of microsporidia in causing gastrointestinal symptoms in this population is as yet unclear.",
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AU - Nordin, Anisah

AU - Aini, U. Nor

AU - Fatmah, M. S.

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