A positive urine pregnancy test (UPT) with adnexal mass; Ectopic pregnancy is not the ultimate diagnosis

Mohd Faizal Ahmad, Muhammad Azrai Abu, Chew Kah Teik, Kun Leng Sheng, Mohd Asyraf Zakaria

Research output: Contribution to journalArticle

Abstract

A positive urine pregnancy test (UPT) with adnexal mass in ectopic pregnancy is not the ultimate diagnosis. The incidence of ectopic pregnancy is about 27 per 1000 pregnancies [1]. On average, about 6-16% will present to an emergency department with first-trimester bleeding and abdominal pain [2]. On presenting with these symptoms with the simultaneous presence of an adnexal mass and an empty uterus, a UPT is of paramount importance to determine whether the symptoms are pregnancy related or not. When the UPT is positive, an ectopic pregnancy is not the only diagnosis as the rare entity of non-gestational ovarian choriocarcinoma (NGOC) should be considered. Here we present two case reports of NGOC, which were initially diagnosed as ectopic pregnancy. The first case is a 16-year-old girl, with vaginal bleeding and an adnexal mass due to an ovarian choriocarcinoma, She underwent unilateral oophorectomy and received multiple courses of chemotherapy. She is disease free without evidence of recurrence or metastasis after 12 months of follow-up. The second patient is also 16 years old and presented with an acute abdomen. She was diagnosed as a ruptured luteal cyst and underwent partial oophorectomy. When the pathologist diagnosed a choriocarcinoma she received multiple courses of chemotherapy, but thereafter an advanced disease was diagnosed with evidence of distant metastasis.

Original languageEnglish
Article number20180004
JournalHormone Molecular Biology and Clinical Investigation
DOIs
Publication statusAccepted/In press - 20 Mar 2018

Fingerprint

Pregnancy Tests
Ectopic Pregnancy
Non-gestational Choriocarcinoma
Urine
Choriocarcinoma
Ovariectomy
Neoplasm Metastasis
Drug Therapy
Pregnancy
Ovarian Cysts
Acute Abdomen
Uterine Hemorrhage
First Pregnancy Trimester
Abdominal Pain
Uterus
Hospital Emergency Service
Hemorrhage
Recurrence
Incidence

Keywords

  • chemotherapy
  • ectopic pregnancy
  • non-gestational
  • ovarian choriocarcinoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Endocrinology

Cite this

A positive urine pregnancy test (UPT) with adnexal mass; Ectopic pregnancy is not the ultimate diagnosis. / Ahmad, Mohd Faizal; Abu, Muhammad Azrai; Kah Teik, Chew; Sheng, Kun Leng; Zakaria, Mohd Asyraf.

In: Hormone Molecular Biology and Clinical Investigation, 20.03.2018.

Research output: Contribution to journalArticle

@article{fdb7577e454047b3b25594288422f77d,
title = "A positive urine pregnancy test (UPT) with adnexal mass; Ectopic pregnancy is not the ultimate diagnosis",
abstract = "A positive urine pregnancy test (UPT) with adnexal mass in ectopic pregnancy is not the ultimate diagnosis. The incidence of ectopic pregnancy is about 27 per 1000 pregnancies [1]. On average, about 6-16{\%} will present to an emergency department with first-trimester bleeding and abdominal pain [2]. On presenting with these symptoms with the simultaneous presence of an adnexal mass and an empty uterus, a UPT is of paramount importance to determine whether the symptoms are pregnancy related or not. When the UPT is positive, an ectopic pregnancy is not the only diagnosis as the rare entity of non-gestational ovarian choriocarcinoma (NGOC) should be considered. Here we present two case reports of NGOC, which were initially diagnosed as ectopic pregnancy. The first case is a 16-year-old girl, with vaginal bleeding and an adnexal mass due to an ovarian choriocarcinoma, She underwent unilateral oophorectomy and received multiple courses of chemotherapy. She is disease free without evidence of recurrence or metastasis after 12 months of follow-up. The second patient is also 16 years old and presented with an acute abdomen. She was diagnosed as a ruptured luteal cyst and underwent partial oophorectomy. When the pathologist diagnosed a choriocarcinoma she received multiple courses of chemotherapy, but thereafter an advanced disease was diagnosed with evidence of distant metastasis.",
keywords = "chemotherapy, ectopic pregnancy, non-gestational, ovarian choriocarcinoma",
author = "Ahmad, {Mohd Faizal} and Abu, {Muhammad Azrai} and {Kah Teik}, Chew and Sheng, {Kun Leng} and Zakaria, {Mohd Asyraf}",
year = "2018",
month = "3",
day = "20",
doi = "10.1515/hmbci-2018-0004",
language = "English",
journal = "Hormone Molecular Biology and Clinical Investigation",
issn = "1868-1883",
publisher = "Walter de Gruyter GmbH",

}

TY - JOUR

T1 - A positive urine pregnancy test (UPT) with adnexal mass; Ectopic pregnancy is not the ultimate diagnosis

AU - Ahmad, Mohd Faizal

AU - Abu, Muhammad Azrai

AU - Kah Teik, Chew

AU - Sheng, Kun Leng

AU - Zakaria, Mohd Asyraf

PY - 2018/3/20

Y1 - 2018/3/20

N2 - A positive urine pregnancy test (UPT) with adnexal mass in ectopic pregnancy is not the ultimate diagnosis. The incidence of ectopic pregnancy is about 27 per 1000 pregnancies [1]. On average, about 6-16% will present to an emergency department with first-trimester bleeding and abdominal pain [2]. On presenting with these symptoms with the simultaneous presence of an adnexal mass and an empty uterus, a UPT is of paramount importance to determine whether the symptoms are pregnancy related or not. When the UPT is positive, an ectopic pregnancy is not the only diagnosis as the rare entity of non-gestational ovarian choriocarcinoma (NGOC) should be considered. Here we present two case reports of NGOC, which were initially diagnosed as ectopic pregnancy. The first case is a 16-year-old girl, with vaginal bleeding and an adnexal mass due to an ovarian choriocarcinoma, She underwent unilateral oophorectomy and received multiple courses of chemotherapy. She is disease free without evidence of recurrence or metastasis after 12 months of follow-up. The second patient is also 16 years old and presented with an acute abdomen. She was diagnosed as a ruptured luteal cyst and underwent partial oophorectomy. When the pathologist diagnosed a choriocarcinoma she received multiple courses of chemotherapy, but thereafter an advanced disease was diagnosed with evidence of distant metastasis.

AB - A positive urine pregnancy test (UPT) with adnexal mass in ectopic pregnancy is not the ultimate diagnosis. The incidence of ectopic pregnancy is about 27 per 1000 pregnancies [1]. On average, about 6-16% will present to an emergency department with first-trimester bleeding and abdominal pain [2]. On presenting with these symptoms with the simultaneous presence of an adnexal mass and an empty uterus, a UPT is of paramount importance to determine whether the symptoms are pregnancy related or not. When the UPT is positive, an ectopic pregnancy is not the only diagnosis as the rare entity of non-gestational ovarian choriocarcinoma (NGOC) should be considered. Here we present two case reports of NGOC, which were initially diagnosed as ectopic pregnancy. The first case is a 16-year-old girl, with vaginal bleeding and an adnexal mass due to an ovarian choriocarcinoma, She underwent unilateral oophorectomy and received multiple courses of chemotherapy. She is disease free without evidence of recurrence or metastasis after 12 months of follow-up. The second patient is also 16 years old and presented with an acute abdomen. She was diagnosed as a ruptured luteal cyst and underwent partial oophorectomy. When the pathologist diagnosed a choriocarcinoma she received multiple courses of chemotherapy, but thereafter an advanced disease was diagnosed with evidence of distant metastasis.

KW - chemotherapy

KW - ectopic pregnancy

KW - non-gestational

KW - ovarian choriocarcinoma

UR - http://www.scopus.com/inward/record.url?scp=85045637167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045637167&partnerID=8YFLogxK

U2 - 10.1515/hmbci-2018-0004

DO - 10.1515/hmbci-2018-0004

M3 - Article

JO - Hormone Molecular Biology and Clinical Investigation

JF - Hormone Molecular Biology and Clinical Investigation

SN - 1868-1883

M1 - 20180004

ER -