A pilot study to determine whether progestogen supplementation using dydrogesterone during the first trimester will reduce the incidence of gestational hypertension in primigravidae

Zainul Rashid Mohd. Razi, Jing Fen Lim, Noorfaizahtul Hanim M Nawawi, Melissha Luqman, Muhammad Faizuddin Zolkeplai, Harry Surya Rangkuty, Natasha Ain Mohamad Nor, Azmi Mohd. Tamil, Shamsul Azhar Shah, Seong Wai Tham, A. E. Schindler

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Gestational hypertension (GH) remains one of the main causes of high maternal and perinatal morbidity and mortality worldwide with the highest incidence among primigravidae of about 10%-15%. However, it was noted that the incidence of GH in primigravidae who conceived following assisted reproductive technique (ART) or intrauterine insemination (IUI) supplemented with dydrogesterone during the first trimester was low. Aim: To determine whether dydrogesterone supplementation during the first trimester can reduce the incidence of GH among primigravidae. Method: A prospective cross-sectional comparative study was undertaken in 2010 on 116 primigravidae (study group) who conceived following ART or IUI and supplemented with dydrogesterone up to 16 weeks gestation. They were matched for age and race at 16 weeks gestation with a control patient from the early pregnancy clinic who were primigravidae (n=116) who conceived spontaneously without dydrogesterone supplementation. Findings: The incidence of GH in the study group was significantly lower than the control group (1.7% versus 12.9%, p=0.001). The incidence of fetal distress was also significantly lower in the study group compared to the control group (4.3% versus 18.1%, p=0.001). Interpretation: Dydrogesterone supplementation during the first trimester significantly reduced the incidence of GH and fetal distress in primigravidae.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalGynecological Endocrinology
Volume30
Issue number3
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Dydrogesterone
Pregnancy Induced Hypertension
Progestins
First Pregnancy Trimester
Incidence
Fetal Distress
Assisted Reproductive Techniques
Insemination
Pregnancy
Control Groups
Perinatal Mortality
Cross-Sectional Studies
Mothers
Morbidity

Keywords

  • Dydrogesterone
  • Gestational hypertension
  • Primigravidae

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology

Cite this

A pilot study to determine whether progestogen supplementation using dydrogesterone during the first trimester will reduce the incidence of gestational hypertension in primigravidae. / Mohd. Razi, Zainul Rashid; Lim, Jing Fen; Nawawi, Noorfaizahtul Hanim M; Luqman, Melissha; Zolkeplai, Muhammad Faizuddin; Rangkuty, Harry Surya; Mohamad Nor, Natasha Ain; Mohd. Tamil, Azmi; Shah, Shamsul Azhar; Tham, Seong Wai; Schindler, A. E.

In: Gynecological Endocrinology, Vol. 30, No. 3, 03.2014, p. 217-220.

Research output: Contribution to journalArticle

Mohd. Razi, Zainul Rashid ; Lim, Jing Fen ; Nawawi, Noorfaizahtul Hanim M ; Luqman, Melissha ; Zolkeplai, Muhammad Faizuddin ; Rangkuty, Harry Surya ; Mohamad Nor, Natasha Ain ; Mohd. Tamil, Azmi ; Shah, Shamsul Azhar ; Tham, Seong Wai ; Schindler, A. E. / A pilot study to determine whether progestogen supplementation using dydrogesterone during the first trimester will reduce the incidence of gestational hypertension in primigravidae. In: Gynecological Endocrinology. 2014 ; Vol. 30, No. 3. pp. 217-220.
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AU - Nawawi, Noorfaizahtul Hanim M

AU - Luqman, Melissha

AU - Zolkeplai, Muhammad Faizuddin

AU - Rangkuty, Harry Surya

AU - Mohamad Nor, Natasha Ain

AU - Mohd. Tamil, Azmi

AU - Shah, Shamsul Azhar

AU - Tham, Seong Wai

AU - Schindler, A. E.

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