A Novel Method for In Vivo Imaging of Solitary Lung Nodules Using Navigational Bronchoscopy and Confocal Laser Microendoscopy

Hassan Tidi Maharani, N. Piton, S. Lachkar, M. Salaün, L. Thiberville

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Solitary pulmonary nodules (SPN) have become increasingly prevalent and diagnostic management remains challenging. We demonstrate a novel technique in which probe-based confocal endomicroscopy (pCLE) could be performed to microimage SPN in vivo and in real-time. Two confocal wavelengths (488 and 660 nm with methylene blue (MB)) were used for elastin network and cellular imaging, respectively using pCLE in conjunction with r-EBUS and virtual navigation. In the first case, the 1-mm Alveoflex® was used to image a metastatic melanoma in a subcentimetric nodule in the right middle lobe. In the next case, a malignant 2-cm nodule in the posterior segment of the upper lobe was imaged using the smaller 0.6-mm Cholangioflex®. Lastly, we present a benign case revealing confocal characteristics of a nodular lipid pneumonitis. This reports for the first time the feasibility and utility of pCLE in vivo microimaging of SPN using either the Alveoflex or Cholangioflex miniprobes in addition to 660 nm/MB imaging.

Original languageEnglish
Pages (from-to)773-778
Number of pages6
JournalLung
Volume193
Issue number5
DOIs
Publication statusPublished - 30 Oct 2015
Externally publishedYes

Fingerprint

Solitary Pulmonary Nodule
Bronchoscopy
Lasers
Methylene Blue
Lung
Elastin
Melanoma
Pneumonia
Lipids

Keywords

  • Bronchoscopy
  • Lung malignancy
  • Probe-based confocal microendoscopy
  • Solitary pulmonary nodules

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

A Novel Method for In Vivo Imaging of Solitary Lung Nodules Using Navigational Bronchoscopy and Confocal Laser Microendoscopy. / Tidi Maharani, Hassan; Piton, N.; Lachkar, S.; Salaün, M.; Thiberville, L.

In: Lung, Vol. 193, No. 5, 30.10.2015, p. 773-778.

Research output: Contribution to journalArticle

Tidi Maharani, Hassan ; Piton, N. ; Lachkar, S. ; Salaün, M. ; Thiberville, L. / A Novel Method for In Vivo Imaging of Solitary Lung Nodules Using Navigational Bronchoscopy and Confocal Laser Microendoscopy. In: Lung. 2015 ; Vol. 193, No. 5. pp. 773-778.
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