A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity

Alhassan Muhammad Alhassan, Qamar Uddin Ahmed, Jalifah Latip, Syed Adnan Ali Shah

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2–6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 9 Feb 2018

Fingerprint

flavone
chemical constituents of plants
alpha-Glucosidases
alpha-glucosidase
flavones
hypoglycemic agents
leaves
Fractionation
Bioactivity
Biological Products
Complex Mixtures
Hypoglycemic Agents
Flavonoids
Sulfates
fractionation
sulfates
flavonoids
Nuclear magnetic resonance
extracts

Keywords

  • alpha-glucosidase inhibitory activity
  • dilleniaceae
  • docking
  • sulphated flavonoid
  • Tetracera indica

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity. / Alhassan, Alhassan Muhammad; Ahmed, Qamar Uddin; Latip, Jalifah; Shah, Syed Adnan Ali.

In: Natural Product Research, 09.02.2018, p. 1-8.

Research output: Contribution to journalArticle

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