A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity

Mariko Kitajima, Kaori Misawa, Noriyuki Kogure, Ikram M. Said, Syunji Horie, Yoshio Hatori, Toshihiko Murayama, Hiromitsu Takayama

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    A new indole alkaloid, 7-hydroxyspeciociliatine (1), was isolated from the fruits of Malaysian Mitragyna speciosa Korth., together with 11 known indole and oxindole alkaloids (3-13). The structure of the new compound was determined by spectroscopic analysis and chemical conversion. The opioid agonistic activity of the new alkaloid was investigated in guinea-pig ileum experiments. The compound was found to have a weak stimulatory effect on μ-opioid receptors.

    Original languageEnglish
    Pages (from-to)28-35
    Number of pages8
    JournalJournal of Natural Medicines
    Volume60
    Issue number1
    DOIs
    Publication statusPublished - Jan 2006

    Fingerprint

    Mitragyna
    Indole Alkaloids
    Fruits
    Alkaloids
    Opioid Analgesics
    Fruit
    Spectroscopic analysis
    Opioid Receptors
    Ileum
    Guinea Pigs
    Experiments

    Keywords

    • μ-Opioid receptor
    • 7-Hydroxyspeciociliatine
    • Indole alkaloid
    • Mitragyna speciosa
    • Opioid agonist
    • Structure determination

    ASJC Scopus subject areas

    • Organic Chemistry
    • Complementary and alternative medicine
    • Drug Discovery
    • Pharmaceutical Science

    Cite this

    A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity. / Kitajima, Mariko; Misawa, Kaori; Kogure, Noriyuki; Said, Ikram M.; Horie, Syunji; Hatori, Yoshio; Murayama, Toshihiko; Takayama, Hiromitsu.

    In: Journal of Natural Medicines, Vol. 60, No. 1, 01.2006, p. 28-35.

    Research output: Contribution to journalArticle

    Kitajima, Mariko ; Misawa, Kaori ; Kogure, Noriyuki ; Said, Ikram M. ; Horie, Syunji ; Hatori, Yoshio ; Murayama, Toshihiko ; Takayama, Hiromitsu. / A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity. In: Journal of Natural Medicines. 2006 ; Vol. 60, No. 1. pp. 28-35.
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