A new bioactive compound from the roots of Petasites hybridus

Fatemeh Khaleghi, Laily Bin Din, Faramarz Rostami Charati, Wan Yaacob Wan Ahmad, Mohammad A. Khalilzadeh, Brian Skelton, Mohamed Makha

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1- benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 μmol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalPhytochemistry Letters
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Petasites hybridus
Petasites
benzofurans
MCF-7 Cells
Cell proliferation
Bovine Serum Albumin
Ultraviolet spectroscopy
Human Activities
Inhibitory Concentration 50
Spectrum Analysis
Cell Proliferation
X-Rays
Breast Neoplasms
Derivatives
X rays
ultraviolet-visible spectroscopy
DNA
bovine serum albumin
breast neoplasms
aqueous solutions

Keywords

  • Benzofuran derivatie
  • Bovine serum albumin (BSA)
  • DNA
  • Human breast cancer MCF-7
  • Petasites hybridus

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Biochemistry
  • Biotechnology

Cite this

Khaleghi, F., Din, L. B., Charati, F. R., Wan Ahmad, W. Y., Khalilzadeh, M. A., Skelton, B., & Makha, M. (2011). A new bioactive compound from the roots of Petasites hybridus. Phytochemistry Letters, 4(3), 254-258. https://doi.org/10.1016/j.phytol.2011.04.009

A new bioactive compound from the roots of Petasites hybridus. / Khaleghi, Fatemeh; Din, Laily Bin; Charati, Faramarz Rostami; Wan Ahmad, Wan Yaacob; Khalilzadeh, Mohammad A.; Skelton, Brian; Makha, Mohamed.

In: Phytochemistry Letters, Vol. 4, No. 3, 09.2011, p. 254-258.

Research output: Contribution to journalArticle

Khaleghi, F, Din, LB, Charati, FR, Wan Ahmad, WY, Khalilzadeh, MA, Skelton, B & Makha, M 2011, 'A new bioactive compound from the roots of Petasites hybridus', Phytochemistry Letters, vol. 4, no. 3, pp. 254-258. https://doi.org/10.1016/j.phytol.2011.04.009
Khaleghi F, Din LB, Charati FR, Wan Ahmad WY, Khalilzadeh MA, Skelton B et al. A new bioactive compound from the roots of Petasites hybridus. Phytochemistry Letters. 2011 Sep;4(3):254-258. https://doi.org/10.1016/j.phytol.2011.04.009
Khaleghi, Fatemeh ; Din, Laily Bin ; Charati, Faramarz Rostami ; Wan Ahmad, Wan Yaacob ; Khalilzadeh, Mohammad A. ; Skelton, Brian ; Makha, Mohamed. / A new bioactive compound from the roots of Petasites hybridus. In: Phytochemistry Letters. 2011 ; Vol. 4, No. 3. pp. 254-258.
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