A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Karimah Kassim, Muhamad Azwan Hamali, Bohari Mohd. Yamin

Research output: Contribution to journalArticle

Abstract

Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction. The analyses showed that the ligands synthesized were formed as azine instead of thiocarbohydrazone based on the missing thione, C=S moiety, throughout FTIR and NMR spectrascopic data. This finding was further concluded by X-ray crystal analysis. The biological properties of these ligands were screened using the disc diffusion method. The result shows that HLb shows significant inhibition towards all of the bacteria tested.

Original languageEnglish
Article number9546373
JournalJournal of Chemistry
Volume2019
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Fingerprint

Microwave irradiation
Ligands
Thiones
Schiff Bases
X ray crystallography
Bacteria
Diffraction
Microwaves
Nuclear magnetic resonance
Spectroscopy
Derivatives
X rays
Crystals

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method. / Kassim, Karimah; Hamali, Muhamad Azwan; Mohd. Yamin, Bohari.

In: Journal of Chemistry, Vol. 2019, 9546373, 01.01.2019.

Research output: Contribution to journalArticle

Kassim, Karimah ; Hamali, Muhamad Azwan ; Mohd. Yamin, Bohari. / A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method. In: Journal of Chemistry. 2019 ; Vol. 2019.
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