A major methicillin-resistant Staphylococcus aureus clone predominates in Malaysian hospitals

A. Norazah, V. K E Lim, M. Y. Rohani, Alfizah Hanafiah, Y. T. Koh, Mohamed Kamel Abdul Ghani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study was conducted to determine the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Malaysian hospitals. A total of 264 MRSA isolates from eight hospitals were subjected to typing by pulsed-field gel electrophoresis (PFGE) of SmaI restricted DNA. Antibiotic disk susceptibility testing was also carried out to determine their resistance patterns. Thirty-one PFGE pattern types were identified. Three major pattern types A, ZC and K were found with type A the predominant profile in c. 80% of strains and present in all hospitals. Unlike type A, other DNA pattern types were unique to the hospitals in which they were isolated. PFGE type A also consisted of strains that were multiply antibiotic resistant. The presence of a single predominant PFGE type in Malaysian hospitals is an important finding which suggests that inter-hospital spread of MRSA had occurred frequently and regularly.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalEpidemiology and Infection
Volume130
Issue number3
DOIs
Publication statusPublished - Jun 2003

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Methicillin-Resistant Staphylococcus aureus
Clone Cells
Pulsed Field Gel Electrophoresis
Anti-Bacterial Agents
Molecular Epidemiology
DNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

A major methicillin-resistant Staphylococcus aureus clone predominates in Malaysian hospitals. / Norazah, A.; Lim, V. K E; Rohani, M. Y.; Hanafiah, Alfizah; Koh, Y. T.; Abdul Ghani, Mohamed Kamel.

In: Epidemiology and Infection, Vol. 130, No. 3, 06.2003, p. 407-411.

Research output: Contribution to journalArticle

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