A highly sensitive fluorescent viscosity sensor

Muhammad Rahimi Usop, Asier Unciti-Broceta, Mark Bradley

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.

Original languageEnglish
Pages (from-to)5780-5783
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number18
DOIs
Publication statusPublished - 15 Sep 2012

Fingerprint

Quantum yield
Fluorescein
Viscosity
Assays
Rotors
Polarization
Derivatives
Sensors
1-methylindole

Keywords

  • Anthofluorescein
  • Fluorescein
  • Palladium catalysis
  • Suzuki cross-coupling
  • Viscosity sensor

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

A highly sensitive fluorescent viscosity sensor. / Usop, Muhammad Rahimi; Unciti-Broceta, Asier; Bradley, Mark.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 18, 15.09.2012, p. 5780-5783.

Research output: Contribution to journalArticle

Usop, Muhammad Rahimi ; Unciti-Broceta, Asier ; Bradley, Mark. / A highly sensitive fluorescent viscosity sensor. In: Bioorganic and Medicinal Chemistry Letters. 2012 ; Vol. 22, No. 18. pp. 5780-5783.
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