A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives

Fatemeh Khaleghi, Laily Bin Din, Ibrahim Jantan, Wan Yaacob Wan Ahmad, Mohammad A. Khalilzadeh

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An efficient and simple synthesis of 1,4-benzoxazepin-2-one derivatives has been achieved via the reaction of isoquinoline, activated acetylenes, and 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone in water without using any catalyst. This one-pot reaction occurs in high yields under mild conditions.

Original languageEnglish
Pages (from-to)7182-7184
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number52
DOIs
Publication statusPublished - 28 Dec 2011

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Alkynes
Derivatives
Catalysts
Water
1-benzofuran
isoquinoline

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Khaleghi, F., Din, L. B., Jantan, I., Wan Ahmad, W. Y., & Khalilzadeh, M. A. (2011). A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives. Tetrahedron Letters, 52(52), 7182-7184. https://doi.org/10.1016/j.tetlet.2011.10.129

A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives. / Khaleghi, Fatemeh; Din, Laily Bin; Jantan, Ibrahim; Wan Ahmad, Wan Yaacob; Khalilzadeh, Mohammad A.

In: Tetrahedron Letters, Vol. 52, No. 52, 28.12.2011, p. 7182-7184.

Research output: Contribution to journalArticle

Khaleghi, F, Din, LB, Jantan, I, Wan Ahmad, WY & Khalilzadeh, MA 2011, 'A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives', Tetrahedron Letters, vol. 52, no. 52, pp. 7182-7184. https://doi.org/10.1016/j.tetlet.2011.10.129
Khaleghi F, Din LB, Jantan I, Wan Ahmad WY, Khalilzadeh MA. A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives. Tetrahedron Letters. 2011 Dec 28;52(52):7182-7184. https://doi.org/10.1016/j.tetlet.2011.10.129
Khaleghi, Fatemeh ; Din, Laily Bin ; Jantan, Ibrahim ; Wan Ahmad, Wan Yaacob ; Khalilzadeh, Mohammad A. / A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives. In: Tetrahedron Letters. 2011 ; Vol. 52, No. 52. pp. 7182-7184.
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