A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland

Haizal M. Hussaini, Christopher M. Angel, Paul M. Speight, Norman A. Firth, Alison M. Rich

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    The hallmark of the histology of epithelial-myoepithelial carcinoma (EMC) is the presence of a regular repetitive mixture of bilayered duct-like structures with an outer layer of myoepithelial cells and inner ductal epithelial cells. Clear cell change in the myoepithelial component is common, but clearing of both cell types, giving an impression of a monocellular neoplasm, is rare. A parotid biopsy was received from an 83-year-old male and subject to routine histologic processing for conventional staining and immunohistochemistry. The encapsulated tumour was composed of sheets of PAS/diastase negative clear cells, separated by fibrous septae. The clear myoepithelial cells were positive for S-100 protein, SMA, and p63 and negative for CK19 and surrounded CK19-positive luminal cells. It is important to utilise immunohistochemistry to differentiate this tumour from others with a similar histologic pattern. Information about the behaviour of the double-clear EMC is limited since there are few cases reported.

    Original languageEnglish
    Pages (from-to)471-475
    Number of pages5
    JournalHead and Neck Pathology
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - Dec 2012

    Fingerprint

    Parotid Gland
    Carcinoma
    Immunohistochemistry
    Neoplasms
    S100 Proteins
    Amylases
    Histology
    Epithelial Cells
    Staining and Labeling
    Biopsy

    Keywords

    • Clear cell tumours
    • Epithelial-myoepithelial carcinoma
    • Salivary gland tumour

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Oncology
    • Otorhinolaryngology

    Cite this

    Hussaini, H. M., Angel, C. M., Speight, P. M., Firth, N. A., & Rich, A. M. (2012). A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland. Head and Neck Pathology, 6(4), 471-475. https://doi.org/10.1007/s12105-012-0350-y

    A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland. / Hussaini, Haizal M.; Angel, Christopher M.; Speight, Paul M.; Firth, Norman A.; Rich, Alison M.

    In: Head and Neck Pathology, Vol. 6, No. 4, 12.2012, p. 471-475.

    Research output: Contribution to journalArticle

    Hussaini, HM, Angel, CM, Speight, PM, Firth, NA & Rich, AM 2012, 'A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland', Head and Neck Pathology, vol. 6, no. 4, pp. 471-475. https://doi.org/10.1007/s12105-012-0350-y
    Hussaini, Haizal M. ; Angel, Christopher M. ; Speight, Paul M. ; Firth, Norman A. ; Rich, Alison M. / A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland. In: Head and Neck Pathology. 2012 ; Vol. 6, No. 4. pp. 471-475.
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