A Cross-Sectional Study on the Dietary Pattern Impact on Cardiovascular Disease Biomarkers in Malaysia

Tilakavati Karupaiah, Khun Aik Chuah, Karuthan Chinna, Peter Pressman, Roger A. Clemens, A. Wallace Hayes, Kalyana Sundram

Research output: Contribution to journalArticle

Abstract

We conducted this cross-sectional population study with a healthy multi-ethnic urban population (n = 577) in Malaysia, combining nutritional assessments with cardiometabolic biomarkers defined by lipid, atherogenic lipoproteins, inflammation and insulin resistance. We found diametrically opposing associations of carbohydrate (246·6 ± 57·7 g, 54·3 ± 6·5%-TEI) and fat (total = 64·5 ± 19·8 g, 31·6 ± 5·5%-TEI; saturated fat = 14·1 ± 2·7%-TEI) intakes as regards waist circumference, HDL-C, blood pressure, glucose, insulin and HOMA2-IR as well as the large-LDL and large-HDL lipoprotein particles. Diets were then differentiated into either low fat (LF, <30% TEI or <50 g) or high fat (HF, >35% TEI or >70 g) and low carbohydrate (LC, <210 g) or high carbohydrate (HC, >285 g) which yielded LFLC, LFHC, HFLC and HFHC groupings. Cardiometabolic biomarkers were not significantly different (P > 0.05) between LFLC and HFLC groups. LFLC had significantly higher large-LDL particle concentrations compared to HFHC. HOMA-IR2 was significantly higher with HFHC (1·91 ± 1·85, P < 0·001) versus other fat-carbohydrate combinations (LFLC = 1·34 ± 1·07, HFLC = 1·41 ± 1·07; LFHC = 1·31 ± 0·93). After co-variate adjustment, odds of having HOMA2-IR >1.7 in the HFHC group was 2.43 (95% CI: 1·03, 5·72) times more compared to LFLC while odds of having large-LDL <450 nmol/L in the HFHC group was 1.91 (95% CI: 1·06, 3·44) more compared to latter group. Our data suggests that a HFHC dietary combination in Malaysian adults is associated with significant impact on lipoprotein particles and insulin resistance.

Original languageEnglish
Article number13666
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Dec 2019

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Malaysia
Cardiovascular Diseases
Cross-Sectional Studies
Biomarkers
Fats
Lipoproteins
Insulin Resistance
Carbohydrates
Nutrition Assessment
Urban Population
Waist Circumference
HDL Lipoproteins
Blood Glucose
Insulin
Diet
Blood Pressure
Inflammation
Lipids
Population
oxidized low density lipoprotein

ASJC Scopus subject areas

  • General

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A Cross-Sectional Study on the Dietary Pattern Impact on Cardiovascular Disease Biomarkers in Malaysia. / Karupaiah, Tilakavati; Chuah, Khun Aik; Chinna, Karuthan; Pressman, Peter; Clemens, Roger A.; Hayes, A. Wallace; Sundram, Kalyana.

In: Scientific reports, Vol. 9, No. 1, 13666, 01.12.2019.

Research output: Contribution to journalArticle

Karupaiah, Tilakavati ; Chuah, Khun Aik ; Chinna, Karuthan ; Pressman, Peter ; Clemens, Roger A. ; Hayes, A. Wallace ; Sundram, Kalyana. / A Cross-Sectional Study on the Dietary Pattern Impact on Cardiovascular Disease Biomarkers in Malaysia. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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