A cross-sectional study of diastolic dysfunction in rheumatoid arthritis and its association with disease activity

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Abstract

Aims: The aim of this study was to evaluate the left ventricular (LV) diastolic dysfunction in rheumatoid arthritis (RA) patients without clinically evident cardiovascular manifestations and to estimate whether there is any correlation between RA disease severity and disability and LV diastolic dysfunction. Methods: The study was a cross-sectional study involving 53 patients (47 female and 6 male) with RA without clinically evident heart disease and 53 healthy subjects (47 female and 6 male) who served as a control group. Both groups were matched for age and sex. Echocardiographic and Doppler studies were conducted in all patients with RA and control subjects. Results: Of 17 cardiac parameters assessed, only two were abnormal. None of the specific cardiac diastolic dysfunction parameters were significantly different in RA patients compared to the control group. There was no significant correlation between diastolic function values in RA patients and value of Disease Activity Score 28 (DAS-28) and value of Health Assessment Questionnaires Disability Index (HAQDI). Atrial (A) wave velocity was greater in RA patients compared to the control group (0.71 [0.58-0.83] vs. 0.61 [0.51-0.71]; P<0.04). However, interventricular relaxation time (IVRT) ([73.08±9.92 vs. 70.74±9.02], P=0.207), lower E/A ratio (1.27 [1.02-1.56] vs. 1.42 [1.20-1.68], P=0.102), diastolic dysfunction parameters according to Redfield Classification (25 [47.2%] vs. 27 [50.9%] P=0.56), diastolic dysfunction using E/A (P=0.321) and tissue doppler imaging (E/E') (P=0.148) were not different. Conclusion: Prevalence of diastolic dysfunction in the rheumatoid arthritis group (47.2%) was not different from controls (50.9%). LV diastolic function had no significant correlation with RA disease severity and duration of disease.

Original languageEnglish
Pages (from-to)18-30
Number of pages13
JournalInternational Journal of Rheumatic Diseases
Volume14
Issue number1
DOIs
Publication statusPublished - Feb 2011

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Rheumatoid Arthritis
Cross-Sectional Studies
Left Ventricular Dysfunction
Control Groups
Left Ventricular Function
Heart Diseases
Healthy Volunteers
Research Design
Health

Keywords

  • DAS-28
  • Diastolic dysfunction
  • HAQDI
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "A cross-sectional study of diastolic dysfunction in rheumatoid arthritis and its association with disease activity",
abstract = "Aims: The aim of this study was to evaluate the left ventricular (LV) diastolic dysfunction in rheumatoid arthritis (RA) patients without clinically evident cardiovascular manifestations and to estimate whether there is any correlation between RA disease severity and disability and LV diastolic dysfunction. Methods: The study was a cross-sectional study involving 53 patients (47 female and 6 male) with RA without clinically evident heart disease and 53 healthy subjects (47 female and 6 male) who served as a control group. Both groups were matched for age and sex. Echocardiographic and Doppler studies were conducted in all patients with RA and control subjects. Results: Of 17 cardiac parameters assessed, only two were abnormal. None of the specific cardiac diastolic dysfunction parameters were significantly different in RA patients compared to the control group. There was no significant correlation between diastolic function values in RA patients and value of Disease Activity Score 28 (DAS-28) and value of Health Assessment Questionnaires Disability Index (HAQDI). Atrial (A) wave velocity was greater in RA patients compared to the control group (0.71 [0.58-0.83] vs. 0.61 [0.51-0.71]; P<0.04). However, interventricular relaxation time (IVRT) ([73.08±9.92 vs. 70.74±9.02], P=0.207), lower E/A ratio (1.27 [1.02-1.56] vs. 1.42 [1.20-1.68], P=0.102), diastolic dysfunction parameters according to Redfield Classification (25 [47.2{\%}] vs. 27 [50.9{\%}] P=0.56), diastolic dysfunction using E/A (P=0.321) and tissue doppler imaging (E/E') (P=0.148) were not different. Conclusion: Prevalence of diastolic dysfunction in the rheumatoid arthritis group (47.2{\%}) was not different from controls (50.9{\%}). LV diastolic function had no significant correlation with RA disease severity and duration of disease.",
keywords = "DAS-28, Diastolic dysfunction, HAQDI, Rheumatoid arthritis",
author = "{Abdul Muizz}, {Abo Malek} and {Mohamed Said}, {Mohd Shahrir} and Shaharir, {Syahrul Sazliyana} and Oteh Maskon and Shah, {Shamsul Azhar} and Heselynn Hussein",
year = "2011",
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doi = "10.1111/j.1756-185X.2010.01593.x",
language = "English",
volume = "14",
pages = "18--30",
journal = "International Journal of Rheumatic Diseases",
issn = "1756-1841",
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T1 - A cross-sectional study of diastolic dysfunction in rheumatoid arthritis and its association with disease activity

AU - Abdul Muizz, Abo Malek

AU - Mohamed Said, Mohd Shahrir

AU - Shaharir, Syahrul Sazliyana

AU - Maskon, Oteh

AU - Shah, Shamsul Azhar

AU - Hussein, Heselynn

PY - 2011/2

Y1 - 2011/2

N2 - Aims: The aim of this study was to evaluate the left ventricular (LV) diastolic dysfunction in rheumatoid arthritis (RA) patients without clinically evident cardiovascular manifestations and to estimate whether there is any correlation between RA disease severity and disability and LV diastolic dysfunction. Methods: The study was a cross-sectional study involving 53 patients (47 female and 6 male) with RA without clinically evident heart disease and 53 healthy subjects (47 female and 6 male) who served as a control group. Both groups were matched for age and sex. Echocardiographic and Doppler studies were conducted in all patients with RA and control subjects. Results: Of 17 cardiac parameters assessed, only two were abnormal. None of the specific cardiac diastolic dysfunction parameters were significantly different in RA patients compared to the control group. There was no significant correlation between diastolic function values in RA patients and value of Disease Activity Score 28 (DAS-28) and value of Health Assessment Questionnaires Disability Index (HAQDI). Atrial (A) wave velocity was greater in RA patients compared to the control group (0.71 [0.58-0.83] vs. 0.61 [0.51-0.71]; P<0.04). However, interventricular relaxation time (IVRT) ([73.08±9.92 vs. 70.74±9.02], P=0.207), lower E/A ratio (1.27 [1.02-1.56] vs. 1.42 [1.20-1.68], P=0.102), diastolic dysfunction parameters according to Redfield Classification (25 [47.2%] vs. 27 [50.9%] P=0.56), diastolic dysfunction using E/A (P=0.321) and tissue doppler imaging (E/E') (P=0.148) were not different. Conclusion: Prevalence of diastolic dysfunction in the rheumatoid arthritis group (47.2%) was not different from controls (50.9%). LV diastolic function had no significant correlation with RA disease severity and duration of disease.

AB - Aims: The aim of this study was to evaluate the left ventricular (LV) diastolic dysfunction in rheumatoid arthritis (RA) patients without clinically evident cardiovascular manifestations and to estimate whether there is any correlation between RA disease severity and disability and LV diastolic dysfunction. Methods: The study was a cross-sectional study involving 53 patients (47 female and 6 male) with RA without clinically evident heart disease and 53 healthy subjects (47 female and 6 male) who served as a control group. Both groups were matched for age and sex. Echocardiographic and Doppler studies were conducted in all patients with RA and control subjects. Results: Of 17 cardiac parameters assessed, only two were abnormal. None of the specific cardiac diastolic dysfunction parameters were significantly different in RA patients compared to the control group. There was no significant correlation between diastolic function values in RA patients and value of Disease Activity Score 28 (DAS-28) and value of Health Assessment Questionnaires Disability Index (HAQDI). Atrial (A) wave velocity was greater in RA patients compared to the control group (0.71 [0.58-0.83] vs. 0.61 [0.51-0.71]; P<0.04). However, interventricular relaxation time (IVRT) ([73.08±9.92 vs. 70.74±9.02], P=0.207), lower E/A ratio (1.27 [1.02-1.56] vs. 1.42 [1.20-1.68], P=0.102), diastolic dysfunction parameters according to Redfield Classification (25 [47.2%] vs. 27 [50.9%] P=0.56), diastolic dysfunction using E/A (P=0.321) and tissue doppler imaging (E/E') (P=0.148) were not different. Conclusion: Prevalence of diastolic dysfunction in the rheumatoid arthritis group (47.2%) was not different from controls (50.9%). LV diastolic function had no significant correlation with RA disease severity and duration of disease.

KW - DAS-28

KW - Diastolic dysfunction

KW - HAQDI

KW - Rheumatoid arthritis

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