A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights

Mohamed Ali Seyed, Ibrahim Jantan, Bukhari Syed Nasir Abbas, Kavitha Vijayaraghavan

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Cancer is a diverse class of diseases characterized by uncontrolled cell growth that constitutes the greatest cause of mortality and morbidity worldwide. Despite steady progress, the treatment modalities of cancer are still insufficient. Several new concepts have emerged for therapeutic intervention in malignant diseases with the goal of identifying specific targets and overcoming resistance against current cytotoxic therapies. Many studies have reported the remarkable and significant properties of dietary plant polyphenols such as curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, epigallocatechin gallate, and cucurbitacin as anticancer agents known for their pleiotropic effects on cancer, immune cells, and inflammation. Piceatannol, an analogue and metabolite of resveratrol, is a natural stilbene commonly found in grape skins and wine. Compared to resveratrol, this molecule exhibits superior bioactivities as an inhibitor of COX-1/2 and the CSN-associated kinase. Piceatannol is thought to be a potent natural compound with many therapeutic effects, such as the prevention of hypercholesterolemia, arrhythmia, atherosclerosis, angiogenesis, and cardiovascular diseases. It also demonstrates vasorelaxation, antioxidant, and anticancer activities. This comprehensive review summarizes the current data regarding the mechanisms of action of piceatannol, its chemopreventive properties, and its possible therapeutic potential against various types of human cancer.

Original languageEnglish
Pages (from-to)725-737
Number of pages13
JournalJournal of Agricultural and Food Chemistry
Volume64
Issue number4
DOIs
Publication statusPublished - 3 Feb 2016

Fingerprint

Oncology
resveratrol
therapeutics
neoplasms
alvocidib
Neoplasms
Cucurbitacins
cucurbitacins
Stilbenes
Curcumin
curcumin
Wine
stilbenes
vasodilation
Cyclooxygenase 2 Inhibitors
hypercholesterolemia
antineoplastic agents
epigallocatechin
arrhythmia
Vitis

Keywords

  • cancer inhibition
  • chemoprevention
  • piceatannol
  • resveratrol
  • therapeutics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights. / Seyed, Mohamed Ali; Jantan, Ibrahim; Syed Nasir Abbas, Bukhari; Vijayaraghavan, Kavitha.

In: Journal of Agricultural and Food Chemistry, Vol. 64, No. 4, 03.02.2016, p. 725-737.

Research output: Contribution to journalArticle

Seyed, Mohamed Ali ; Jantan, Ibrahim ; Syed Nasir Abbas, Bukhari ; Vijayaraghavan, Kavitha. / A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights. In: Journal of Agricultural and Food Chemistry. 2016 ; Vol. 64, No. 4. pp. 725-737.
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