A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Sumaira Saleem, Gulzar Muhammad, Muhammad Ajaz Hussain, Bukhari Syed Nasir Abbas

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti-inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties. A. indica is also rich in various phytochemicals for pharmaceuticals such as alkaloids, steroids, flavonoids, terpenoids, fatty acids, and carbohydrates. The fungicidal potential of the tree is due to the presence of azadirachtin and nimbin. Herein, we have compiled a comprehensive review of phytochemical profile, pharmacological attributes, and therapeutic prospective of this multipurpose tree.

Original languageEnglish
Pages (from-to)1241-1272
Number of pages32
JournalPhytotherapy Research
Volume32
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018
Externally publishedYes

Fingerprint

Azadirachta
Phytochemicals
Pharmacology
Hypoglycemic Agents
Pharmaceutical Preparations
Meliaceae
Antipyretics
Chickenpox
Dengue
Terpenes
Leprosy
Pedigree
Alkaloids
Flavonoids
Malaria
Ulcer
Headache
Anti-Inflammatory Agents
Fever
Fatty Acids

Keywords

  • Azadirachta indica
  • azadirachtin
  • bioactives
  • medicinal uses
  • neem
  • pharmacological attributes
  • secondary metabolites

ASJC Scopus subject areas

  • Pharmacology

Cite this

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica. / Saleem, Sumaira; Muhammad, Gulzar; Hussain, Muhammad Ajaz; Syed Nasir Abbas, Bukhari.

In: Phytotherapy Research, Vol. 32, No. 7, 01.07.2018, p. 1241-1272.

Research output: Contribution to journalReview article

Saleem, Sumaira ; Muhammad, Gulzar ; Hussain, Muhammad Ajaz ; Syed Nasir Abbas, Bukhari. / A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica. In: Phytotherapy Research. 2018 ; Vol. 32, No. 7. pp. 1241-1272.
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