A Comparative study of transmembrane diffusion and permeation of ibuprofen across synthetic membranes using franz diffusion cells

Shiow Fern Ng, Jennifer Rouse, Dominic Sanderson, Gillian Eccleston

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Synthetic membranes used in Franz diffusion cells for topical formulation quality assessment should provide least resistance to drug diffusion. In this study, the diffusion rates of ibuprofen across thirteen membranes were determined using Franz diffusion cells. Correlation of the membrane thickness, pore size and MWCO with drug fluxes was also made. The drug diffusion results showed that the porous membranes were categorized into high-flux (8-18 mg/cm2/h) and low-flux (0.1-3 mg/cm2/h) membranes. The drug fluxes did not show strong correlations (r2 < 0.99) with membrane parameters. Synthetic membranes can give variable drug fluxes, thus investigators should be careful in choosing membrane for formulation quality assessment.

Original languageEnglish
Pages (from-to)209-223
Number of pages15
JournalPharmaceutics
Volume2
Issue number2
DOIs
Publication statusPublished - Jun 2010

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Ibuprofen
Membranes
Pharmaceutical Preparations
Drug Resistance
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Keywords

  • Franz diffusion cells
  • Ibuprofen drug diffusion
  • In vitro absorption
  • Synthetic membranes
  • Transdermal absorption

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

A Comparative study of transmembrane diffusion and permeation of ibuprofen across synthetic membranes using franz diffusion cells. / Ng, Shiow Fern; Rouse, Jennifer; Sanderson, Dominic; Eccleston, Gillian.

In: Pharmaceutics, Vol. 2, No. 2, 06.2010, p. 209-223.

Research output: Contribution to journalArticle

Ng, Shiow Fern ; Rouse, Jennifer ; Sanderson, Dominic ; Eccleston, Gillian. / A Comparative study of transmembrane diffusion and permeation of ibuprofen across synthetic membranes using franz diffusion cells. In: Pharmaceutics. 2010 ; Vol. 2, No. 2. pp. 209-223.
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