A comparative study of the compaction properties of binary and bilayer tablets of direct compression excipients

Mohd Cairul Iqbal Mohd Amin, Sami Mohammed Albawani, Muhammad Wahab Amjad

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: To comparatively evaluate the tableting properties of binary mixtures and bilayer tablets containing plastic deformation and brittle fracture excipients. Methods: Binary mixture and bilayer tablets of microcrystalline cellulose (MCC), ethyl cellulose, anhydrous lactose and dextrate were prepared by direct compression and the effect of compaction pressure on the materials was investigated by scanning electron microscopy (SEM). True, bulk and tap densities of excipients were determined. Furthermore, Heckel equation and Carr's index were used to analyze the compression behaviour of the tablets. Results: The flowability of dextrate, based on Heckel and Carr's Index data, was superior to that of other powder excipients tested. No significant difference was observed between the tensile strength of binary and bilayer tablets of the same composition. However, the tensile strength of binary and bilayer tablets of different compositions varied significantly (p < 0.001), e.g., the tensile strength of microcrystalline cellulose (MCC)/ethyl cellulose (EC) tablets (50/50) was 1.77 MPa while that of MCC/dextrate at 50/50 composition was 1.47 MPa. Conclusion: Binary mixture and bilayer tablets show similar behaviour when formulated using excipients of similar deformation properties. However, their behavior changes when excipients with different deformation properties are blended together.

Original languageEnglish
Pages (from-to)585-594
Number of pages10
JournalTropical Journal of Pharmaceutical Research
Volume11
Issue number4
Publication statusPublished - Aug 2012

Fingerprint

Excipients
Tablets
Tensile Strength
Lactose
Electron Scanning Microscopy
Powders
Plastics
Pressure
microcrystalline cellulose

Keywords

  • Bilayer tablet
  • Binary mixture
  • Brittle fracture
  • Plastic deformation
  • Tensile strength

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

A comparative study of the compaction properties of binary and bilayer tablets of direct compression excipients. / Mohd Amin, Mohd Cairul Iqbal; Albawani, Sami Mohammed; Amjad, Muhammad Wahab.

In: Tropical Journal of Pharmaceutical Research, Vol. 11, No. 4, 08.2012, p. 585-594.

Research output: Contribution to journalArticle

@article{2c56afc91beb463d887ab3369e615145,
title = "A comparative study of the compaction properties of binary and bilayer tablets of direct compression excipients",
abstract = "Purpose: To comparatively evaluate the tableting properties of binary mixtures and bilayer tablets containing plastic deformation and brittle fracture excipients. Methods: Binary mixture and bilayer tablets of microcrystalline cellulose (MCC), ethyl cellulose, anhydrous lactose and dextrate were prepared by direct compression and the effect of compaction pressure on the materials was investigated by scanning electron microscopy (SEM). True, bulk and tap densities of excipients were determined. Furthermore, Heckel equation and Carr's index were used to analyze the compression behaviour of the tablets. Results: The flowability of dextrate, based on Heckel and Carr's Index data, was superior to that of other powder excipients tested. No significant difference was observed between the tensile strength of binary and bilayer tablets of the same composition. However, the tensile strength of binary and bilayer tablets of different compositions varied significantly (p < 0.001), e.g., the tensile strength of microcrystalline cellulose (MCC)/ethyl cellulose (EC) tablets (50/50) was 1.77 MPa while that of MCC/dextrate at 50/50 composition was 1.47 MPa. Conclusion: Binary mixture and bilayer tablets show similar behaviour when formulated using excipients of similar deformation properties. However, their behavior changes when excipients with different deformation properties are blended together.",
keywords = "Bilayer tablet, Binary mixture, Brittle fracture, Plastic deformation, Tensile strength",
author = "{Mohd Amin}, {Mohd Cairul Iqbal} and Albawani, {Sami Mohammed} and Amjad, {Muhammad Wahab}",
year = "2012",
month = "8",
language = "English",
volume = "11",
pages = "585--594",
journal = "Tropical Journal of Pharmaceutical Research",
issn = "1596-5996",
publisher = "Pharmacotherapy Group",
number = "4",

}

TY - JOUR

T1 - A comparative study of the compaction properties of binary and bilayer tablets of direct compression excipients

AU - Mohd Amin, Mohd Cairul Iqbal

AU - Albawani, Sami Mohammed

AU - Amjad, Muhammad Wahab

PY - 2012/8

Y1 - 2012/8

N2 - Purpose: To comparatively evaluate the tableting properties of binary mixtures and bilayer tablets containing plastic deformation and brittle fracture excipients. Methods: Binary mixture and bilayer tablets of microcrystalline cellulose (MCC), ethyl cellulose, anhydrous lactose and dextrate were prepared by direct compression and the effect of compaction pressure on the materials was investigated by scanning electron microscopy (SEM). True, bulk and tap densities of excipients were determined. Furthermore, Heckel equation and Carr's index were used to analyze the compression behaviour of the tablets. Results: The flowability of dextrate, based on Heckel and Carr's Index data, was superior to that of other powder excipients tested. No significant difference was observed between the tensile strength of binary and bilayer tablets of the same composition. However, the tensile strength of binary and bilayer tablets of different compositions varied significantly (p < 0.001), e.g., the tensile strength of microcrystalline cellulose (MCC)/ethyl cellulose (EC) tablets (50/50) was 1.77 MPa while that of MCC/dextrate at 50/50 composition was 1.47 MPa. Conclusion: Binary mixture and bilayer tablets show similar behaviour when formulated using excipients of similar deformation properties. However, their behavior changes when excipients with different deformation properties are blended together.

AB - Purpose: To comparatively evaluate the tableting properties of binary mixtures and bilayer tablets containing plastic deformation and brittle fracture excipients. Methods: Binary mixture and bilayer tablets of microcrystalline cellulose (MCC), ethyl cellulose, anhydrous lactose and dextrate were prepared by direct compression and the effect of compaction pressure on the materials was investigated by scanning electron microscopy (SEM). True, bulk and tap densities of excipients were determined. Furthermore, Heckel equation and Carr's index were used to analyze the compression behaviour of the tablets. Results: The flowability of dextrate, based on Heckel and Carr's Index data, was superior to that of other powder excipients tested. No significant difference was observed between the tensile strength of binary and bilayer tablets of the same composition. However, the tensile strength of binary and bilayer tablets of different compositions varied significantly (p < 0.001), e.g., the tensile strength of microcrystalline cellulose (MCC)/ethyl cellulose (EC) tablets (50/50) was 1.77 MPa while that of MCC/dextrate at 50/50 composition was 1.47 MPa. Conclusion: Binary mixture and bilayer tablets show similar behaviour when formulated using excipients of similar deformation properties. However, their behavior changes when excipients with different deformation properties are blended together.

KW - Bilayer tablet

KW - Binary mixture

KW - Brittle fracture

KW - Plastic deformation

KW - Tensile strength

UR - http://www.scopus.com/inward/record.url?scp=84865695902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865695902&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84865695902

VL - 11

SP - 585

EP - 594

JO - Tropical Journal of Pharmaceutical Research

JF - Tropical Journal of Pharmaceutical Research

SN - 1596-5996

IS - 4

ER -