A case report of haemolytic disease of foetus and newborn due to anti-E antibody in a primigravida patient

Research output: Contribution to journalArticle

Abstract

Anti-E antibody is one of the frequently encountered alloantibody of the Rh blood group system; however, it is seldom implicated in haemolytic disease of the foetus and newborn (HDFN). This case report describes a mild HDFN due to anti-E antibody in a full term baby-girl born to a primigravida patient. The baby developed jaundice on the first dayof-life. Blood group of both mother and the baby was B positive and Rh phenotype was CDe/CDe (R1R1) and CDe/cDE (R1R2) respectively. Anti-E and anti-c was identified in the mother while baby’s blood showed weak positive Direct Antiglobulin Test with anti-E identified from the baby’s serum. The baby was started on phototherapy and was discharged well on day -6. Although this was a mild HDFN, we would like to highlight the importance of antenatal screening for pregnant mothers. The antibody screening for Rh positive mothers is not a routine practice in many centers in Malaysia due to cost–benefit constraints. However, we would like to suggest to include the antenatal red cell antibody screening test for all pregnant mothers at least during the 1st antenatal booking to enable early detection of alloantibody which may cause HDFN, thus enable close monitoring of foetus and initiate early management as needed.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalBangladesh Journal of Medical Science
Volume15
Issue number1
Publication statusPublished - 2016

Fingerprint

Fetal Erythroblastosis
Anti-Idiotypic Antibodies
Fetus
Mothers
Isoantibodies
Blood Group Antigens
Coombs Test
Phototherapy
Antibodies
Malaysia
Jaundice
Prenatal Diagnosis
Phenotype
Serum

Keywords

  • Allo antibody
  • Antenatal antibody screening
  • Anti-E
  • HDFN

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "A case report of haemolytic disease of foetus and newborn due to anti-E antibody in a primigravida patient",
abstract = "Anti-E antibody is one of the frequently encountered alloantibody of the Rh blood group system; however, it is seldom implicated in haemolytic disease of the foetus and newborn (HDFN). This case report describes a mild HDFN due to anti-E antibody in a full term baby-girl born to a primigravida patient. The baby developed jaundice on the first dayof-life. Blood group of both mother and the baby was B positive and Rh phenotype was CDe/CDe (R1R1) and CDe/cDE (R1R2) respectively. Anti-E and anti-c was identified in the mother while baby’s blood showed weak positive Direct Antiglobulin Test with anti-E identified from the baby’s serum. The baby was started on phototherapy and was discharged well on day -6. Although this was a mild HDFN, we would like to highlight the importance of antenatal screening for pregnant mothers. The antibody screening for Rh positive mothers is not a routine practice in many centers in Malaysia due to cost–benefit constraints. However, we would like to suggest to include the antenatal red cell antibody screening test for all pregnant mothers at least during the 1st antenatal booking to enable early detection of alloantibody which may cause HDFN, thus enable close monitoring of foetus and initiate early management as needed.",
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AU - Abdul Aziz, Suria

AU - Chooi Fun, Leong

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AB - Anti-E antibody is one of the frequently encountered alloantibody of the Rh blood group system; however, it is seldom implicated in haemolytic disease of the foetus and newborn (HDFN). This case report describes a mild HDFN due to anti-E antibody in a full term baby-girl born to a primigravida patient. The baby developed jaundice on the first dayof-life. Blood group of both mother and the baby was B positive and Rh phenotype was CDe/CDe (R1R1) and CDe/cDE (R1R2) respectively. Anti-E and anti-c was identified in the mother while baby’s blood showed weak positive Direct Antiglobulin Test with anti-E identified from the baby’s serum. The baby was started on phototherapy and was discharged well on day -6. Although this was a mild HDFN, we would like to highlight the importance of antenatal screening for pregnant mothers. The antibody screening for Rh positive mothers is not a routine practice in many centers in Malaysia due to cost–benefit constraints. However, we would like to suggest to include the antenatal red cell antibody screening test for all pregnant mothers at least during the 1st antenatal booking to enable early detection of alloantibody which may cause HDFN, thus enable close monitoring of foetus and initiate early management as needed.

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