A case of herpes simplex virus type 1 (HSV-1) encephalitis as a possible complication of cosmetic nasal dermal filler injection

Ching Soong Khoo, Hui Jan Tan, Syazarina Sharis Osman

Research output: Contribution to journalArticle

Abstract

Objective: Unusual or unexpected effect of treatment Background: Dermal fillers are increasingly used for medical and aesthetic purposes in clinical practice. Common complications following filler injections include bruising, itching, infections, allergic reactions, and tissue necrosis. This case is the first report of Herpes simplex virus type 1 (HSV-1) encephalitis as a possible complication of dermal filler injection. Case Report: A 27-year-old woman with no past medical history presented with altered mental state, headaches, and seizures. She had a nasal dermal filler injection for aesthetic purpose five weeks before her acute presentation. A diagnosis of HSV-1 encephalitis was made based on brain imaging with computed tomography and magnetic resonance imaging (MRI) findings that showed bilateral frontotemporal lobe hyperintensity. Analysis of her ce-rebrospinal fluid (CSF) confirmed the presence of HSV-1 DNA. Despite anti-viral treatment with acyclovir, she developed postencephalitic syndrome. Conclusions: This case report highlights the possibility that among the complications of the use of cosmetic dermal fillers, the transmission of HSV-1 and the development of HSV-1 encephalitis should be recognized.

LanguageEnglish
Pages825-828
Number of pages4
JournalAmerican Journal of Case Reports
Volume19
DOIs
Publication statusPublished - 13 Jul 2018

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Human Herpesvirus 1
Encephalitis
Nose
Cosmetics
Injections
Esthetics
Acyclovir
Pruritus
Neuroimaging
Headache
Hypersensitivity
Seizures
Necrosis
Tomography
Magnetic Resonance Imaging
Dermal Fillers
DNA
Therapeutics
Infection

Keywords

  • Acyclovir
  • Encephalitis
  • Herpes simplex
  • Status epilepticus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A case of herpes simplex virus type 1 (HSV-1) encephalitis as a possible complication of cosmetic nasal dermal filler injection. / Khoo, Ching Soong; Tan, Hui Jan; Osman, Syazarina Sharis.

In: American Journal of Case Reports, Vol. 19, 13.07.2018, p. 825-828.

Research output: Contribution to journalArticle

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