A case of chronic myeloid leukaemia in blast transformation with leukemic ascites

Mohd Ridzuan Mohd Said, Sze Wei Yap, Wan Fariza Wan Jamaluddin, S Fadilah S. Abdul Wahid, Salwati Shuib

Research output: Contribution to journalArticle

Abstract

Chronic Myeloid Leukaemia (CML) is a disease characterised by a distinctive marker that is the Philadelphia Chromosome and an ability to transform into blast phase, which confers a poor prognosis. The median survival was reported to be between three to six months in correlation to blast phase. Extramedullary involvement with CML to sites such as pleural, meningeal and bones have been reported. We report a case of 41-year-old man who was diagnosed with CML in blast phase and presented with ascites. Ultrasound of abdomen showed coarse echotexture of liver suggestive leukaemic infiltration to the liver. The liver profile was severely deranged and associated with coagulopathy. Flow cytometry analysis of the peritoneal fluid revealed presence of myeloblasts consistent with CML in blast crisis with leukaemic ascites. Bone marrow biopsy also confirmed disease transformation. He received standard induction chemotherapy for acute myeloid leukaemia with dose modifications based on liver enzymes performance. Our case highlights an unusual presentation of CML in blast crisis with leukaemic ascites and the challenges in managing cytotoxic treatments due to the liver infiltration.

Original languageEnglish
Pages (from-to)85-87
Number of pages3
JournalMedical Journal of Malaysia
Volume71
Issue number2
Publication statusPublished - 1 Apr 2016

Fingerprint

Blast Crisis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphocyte Activation
Ascites
Liver
Granulocyte Precursor Cells
Philadelphia Chromosome
Induction Chemotherapy
Ascitic Fluid
Acute Myeloid Leukemia
Abdomen
Flow Cytometry
Bone Marrow
Biopsy
Bone and Bones
Survival
Enzymes

Keywords

  • Blast phase
  • CML
  • Leukaemic ascites
  • Liver infiltration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A case of chronic myeloid leukaemia in blast transformation with leukemic ascites. / Mohd Said, Mohd Ridzuan; Yap, Sze Wei; Jamaluddin, Wan Fariza Wan; S. Abdul Wahid, S Fadilah; Shuib, Salwati.

In: Medical Journal of Malaysia, Vol. 71, No. 2, 01.04.2016, p. 85-87.

Research output: Contribution to journalArticle

Mohd Said, Mohd Ridzuan ; Yap, Sze Wei ; Jamaluddin, Wan Fariza Wan ; S. Abdul Wahid, S Fadilah ; Shuib, Salwati. / A case of chronic myeloid leukaemia in blast transformation with leukemic ascites. In: Medical Journal of Malaysia. 2016 ; Vol. 71, No. 2. pp. 85-87.
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