3-bromo-1-hydroxy-9,10-anthraquinone (BHAQ) inhibits growth and migration of the human breast cancer cell lines MCF-7 and MDA-MB231

Nadiah Abu, M. Nadeem Akhtar, Wan Yong Ho, Swee Keong Yeap, Noorjahan Banu Alitheen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.

Original languageEnglish
Pages (from-to)10367-10377
Number of pages11
JournalMolecules
Volume18
Issue number9
DOIs
Publication statusPublished - 1 Sep 2013
Externally publishedYes

Fingerprint

multiple docking adapters
anthraquinones
cultured cells
breast
Anthraquinones
cancer
Cells
Breast Neoplasms
Cell Line
Growth
Acridine Orange
Propidium
Wound Healing
Cell Cycle
wound healing
Staining and Labeling
staining
Assays
iodides
chambers

Keywords

  • Anthraquinone
  • BHAQ
  • Cytotoxic
  • MCF-7
  • MDA-MB231
  • Migration

ASJC Scopus subject areas

  • Medicine(all)
  • Organic Chemistry

Cite this

3-bromo-1-hydroxy-9,10-anthraquinone (BHAQ) inhibits growth and migration of the human breast cancer cell lines MCF-7 and MDA-MB231. / Abu, Nadiah; Akhtar, M. Nadeem; Ho, Wan Yong; Yeap, Swee Keong; Alitheen, Noorjahan Banu.

In: Molecules, Vol. 18, No. 9, 01.09.2013, p. 10367-10377.

Research output: Contribution to journalArticle

Abu, Nadiah ; Akhtar, M. Nadeem ; Ho, Wan Yong ; Yeap, Swee Keong ; Alitheen, Noorjahan Banu. / 3-bromo-1-hydroxy-9,10-anthraquinone (BHAQ) inhibits growth and migration of the human breast cancer cell lines MCF-7 and MDA-MB231. In: Molecules. 2013 ; Vol. 18, No. 9. pp. 10367-10377.
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