Abstract
Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.
| Original language | English |
|---|---|
| Pages (from-to) | 10367-10377 |
| Number of pages | 11 |
| Journal | Molecules |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Sep 2013 |
| Externally published | Yes |
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Keywords
- Anthraquinone
- BHAQ
- Cytotoxic
- MCF-7
- MDA-MB231
- Migration
ASJC Scopus subject areas
- Medicine(all)
- Organic Chemistry
Cite this
3-bromo-1-hydroxy-9,10-anthraquinone (BHAQ) inhibits growth and migration of the human breast cancer cell lines MCF-7 and MDA-MB231. / Abu, Nadiah; Akhtar, M. Nadeem; Ho, Wan Yong; Yeap, Swee Keong; Alitheen, Noorjahan Banu.
In: Molecules, Vol. 18, No. 9, 01.09.2013, p. 10367-10377.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 3-bromo-1-hydroxy-9,10-anthraquinone (BHAQ) inhibits growth and migration of the human breast cancer cell lines MCF-7 and MDA-MB231
AU - Abu, Nadiah
AU - Akhtar, M. Nadeem
AU - Ho, Wan Yong
AU - Yeap, Swee Keong
AU - Alitheen, Noorjahan Banu
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.
AB - Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.
KW - Anthraquinone
KW - BHAQ
KW - Cytotoxic
KW - MCF-7
KW - MDA-MB231
KW - Migration
UR - http://www.scopus.com/inward/record.url?scp=84885146995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885146995&partnerID=8YFLogxK
U2 - 10.3390/molecules180910367
DO - 10.3390/molecules180910367
M3 - Article
VL - 18
SP - 10367
EP - 10377
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 9
ER -