2005 Young investigator's award winner: Assessment of diastolic function in newly diagnosed hypertensives

Masliza Mahmod, S. Mohd Daud, Y. Khalid

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: The prevalence and severity of diastolic dysfunction (DD) among newly diagnosed hypertensives (NDHT) is not fully established. The aim of this study was to evaluate left ventricular diastolic junction (LVDF) in patients with NDHT. Materials and Methods: This study involved 396 subjects (198 NDHT, age and gender matched 198 normotensives; age, 30 to 50 years). Parameters of LVDF included Doppler-echocardiographic measurements of peak early (E) and late (A) diastolic velocities, E-wave deceleration time (DT) and isovolumetric relaxation time (IVRT). E/A ratio of <1 was taken as an indicative of DD. Results: Patients with NDHT had reduced E/A ratio (1.27 ± 0.41 vs 1.37 ± 0.35, P <0.001) and shortened DT (180.0 ± 40.0 ms vs 190.0 ± 30.0 ms, P = 0.025). The peak A velocity and IVRT were increased in the NDHT group [(62.73 ± 13.82 ms vs 58.26 ± 12.40 ms, P = 0.002) and (90.0 ± 20.0 ms vs 80.0 ± 10.0 ms, P <0.001), respectively]. Peak E velocity was similar in both groups. The prevalence of DD was increased in the NDHT group, 18.6% (32) vs 3.4% (6), P <0.001. Of the 32 NDHT subjects who had DD, 84.4% (27) had no left ventricular hypertrophy (LVH) and 15.7% (5) had LVH. Diastolic function was negatively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure and left ventricular mass index. Conclusion: Impairment in LVDF occurs in NDHT which may precede structural abnormalities. Hypertension, obesity, older age and LVH are associated with worsenine of diastolic function.

Original languageEnglish
Pages (from-to)684-688
Number of pages5
JournalAnnals of the Academy of Medicine Singapore
Volume34
Issue number11
Publication statusPublished - Dec 2005

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Left Ventricular Hypertrophy
Research Personnel
Blood Pressure
Deceleration
Body Mass Index
Obesity
Hypertension

Keywords

  • Diastolic dysfunction
  • Diastolic heart failure
  • Left atrial size
  • Left ventricular hypertrophy
  • Left ventricular mass index

ASJC Scopus subject areas

  • Medicine(all)

Cite this

2005 Young investigator's award winner : Assessment of diastolic function in newly diagnosed hypertensives. / Mahmod, Masliza; Mohd Daud, S.; Khalid, Y.

In: Annals of the Academy of Medicine Singapore, Vol. 34, No. 11, 12.2005, p. 684-688.

Research output: Contribution to journalArticle

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abstract = "Introduction: The prevalence and severity of diastolic dysfunction (DD) among newly diagnosed hypertensives (NDHT) is not fully established. The aim of this study was to evaluate left ventricular diastolic junction (LVDF) in patients with NDHT. Materials and Methods: This study involved 396 subjects (198 NDHT, age and gender matched 198 normotensives; age, 30 to 50 years). Parameters of LVDF included Doppler-echocardiographic measurements of peak early (E) and late (A) diastolic velocities, E-wave deceleration time (DT) and isovolumetric relaxation time (IVRT). E/A ratio of <1 was taken as an indicative of DD. Results: Patients with NDHT had reduced E/A ratio (1.27 ± 0.41 vs 1.37 ± 0.35, P <0.001) and shortened DT (180.0 ± 40.0 ms vs 190.0 ± 30.0 ms, P = 0.025). The peak A velocity and IVRT were increased in the NDHT group [(62.73 ± 13.82 ms vs 58.26 ± 12.40 ms, P = 0.002) and (90.0 ± 20.0 ms vs 80.0 ± 10.0 ms, P <0.001), respectively]. Peak E velocity was similar in both groups. The prevalence of DD was increased in the NDHT group, 18.6{\%} (32) vs 3.4{\%} (6), P <0.001. Of the 32 NDHT subjects who had DD, 84.4{\%} (27) had no left ventricular hypertrophy (LVH) and 15.7{\%} (5) had LVH. Diastolic function was negatively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure and left ventricular mass index. Conclusion: Impairment in LVDF occurs in NDHT which may precede structural abnormalities. Hypertension, obesity, older age and LVH are associated with worsenine of diastolic function.",
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N2 - Introduction: The prevalence and severity of diastolic dysfunction (DD) among newly diagnosed hypertensives (NDHT) is not fully established. The aim of this study was to evaluate left ventricular diastolic junction (LVDF) in patients with NDHT. Materials and Methods: This study involved 396 subjects (198 NDHT, age and gender matched 198 normotensives; age, 30 to 50 years). Parameters of LVDF included Doppler-echocardiographic measurements of peak early (E) and late (A) diastolic velocities, E-wave deceleration time (DT) and isovolumetric relaxation time (IVRT). E/A ratio of <1 was taken as an indicative of DD. Results: Patients with NDHT had reduced E/A ratio (1.27 ± 0.41 vs 1.37 ± 0.35, P <0.001) and shortened DT (180.0 ± 40.0 ms vs 190.0 ± 30.0 ms, P = 0.025). The peak A velocity and IVRT were increased in the NDHT group [(62.73 ± 13.82 ms vs 58.26 ± 12.40 ms, P = 0.002) and (90.0 ± 20.0 ms vs 80.0 ± 10.0 ms, P <0.001), respectively]. Peak E velocity was similar in both groups. The prevalence of DD was increased in the NDHT group, 18.6% (32) vs 3.4% (6), P <0.001. Of the 32 NDHT subjects who had DD, 84.4% (27) had no left ventricular hypertrophy (LVH) and 15.7% (5) had LVH. Diastolic function was negatively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure and left ventricular mass index. Conclusion: Impairment in LVDF occurs in NDHT which may precede structural abnormalities. Hypertension, obesity, older age and LVH are associated with worsenine of diastolic function.

AB - Introduction: The prevalence and severity of diastolic dysfunction (DD) among newly diagnosed hypertensives (NDHT) is not fully established. The aim of this study was to evaluate left ventricular diastolic junction (LVDF) in patients with NDHT. Materials and Methods: This study involved 396 subjects (198 NDHT, age and gender matched 198 normotensives; age, 30 to 50 years). Parameters of LVDF included Doppler-echocardiographic measurements of peak early (E) and late (A) diastolic velocities, E-wave deceleration time (DT) and isovolumetric relaxation time (IVRT). E/A ratio of <1 was taken as an indicative of DD. Results: Patients with NDHT had reduced E/A ratio (1.27 ± 0.41 vs 1.37 ± 0.35, P <0.001) and shortened DT (180.0 ± 40.0 ms vs 190.0 ± 30.0 ms, P = 0.025). The peak A velocity and IVRT were increased in the NDHT group [(62.73 ± 13.82 ms vs 58.26 ± 12.40 ms, P = 0.002) and (90.0 ± 20.0 ms vs 80.0 ± 10.0 ms, P <0.001), respectively]. Peak E velocity was similar in both groups. The prevalence of DD was increased in the NDHT group, 18.6% (32) vs 3.4% (6), P <0.001. Of the 32 NDHT subjects who had DD, 84.4% (27) had no left ventricular hypertrophy (LVH) and 15.7% (5) had LVH. Diastolic function was negatively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure and left ventricular mass index. Conclusion: Impairment in LVDF occurs in NDHT which may precede structural abnormalities. Hypertension, obesity, older age and LVH are associated with worsenine of diastolic function.

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KW - Diastolic heart failure

KW - Left atrial size

KW - Left ventricular hypertrophy

KW - Left ventricular mass index

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