11β-hydroxysteroid dehydrogenase bioactivity is increased in the colon but not kidneys of rats given supplementary thyroxine

Ruszymah Idrus, Zaiton Zakaria, S. Aminuddin, B. A K Khalid

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to investigate the effect of altered thyroid status on 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD type 1) and type 2 (11β-HSD type 2) bioactivity in rat kidney and colon. Male Sprague-Dawley rats (250g) were treated with either L-thyroxine (T4) or propylthiouracil (PTU) for 4 weeks. Blood were then analysed for serum thyroxine, sodium (Na+) and potassium (K+). The kidneys and colon were assayed for 11β-HSD type 1 and 11β-HSD type 2 bioactivity. In T4 treated rats the serum thyroxine was significantly elevated (p<0.05) whilst PTU decreased serum thyroxine significantly (p<0.001) compared to controls. Serum Na+ and K+ were within normal limits. There were no significant changes in 11β-HSD type 1 bioactivity in both treatment groups compared to controls. However, the 11β-HSD type 2 bioactivity in rats given thyroxine was significantly higher in the colon (p<0.003) compared to controls. We conclude that altered thyroid status had no effect on 11β-HSD type 1 bioactivity but 11β-HSD type 2 bioactivity was elevated in the colon of rats given supplementary thyroxine.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalExperimental and Clinical Endocrinology and Diabetes
Volume109
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

11-beta-Hydroxysteroid Dehydrogenases
Thyroxine
Colon
Kidney
Propylthiouracil
Serum
Thyroid Gland
Sprague Dawley Rats
Potassium
Sodium

Keywords

  • 11β-hydroxysteroid
  • Dehydrogenase
  • Propylthiouracil
  • Serum potassium
  • Serum sodium
  • Thyroxine

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

11β-hydroxysteroid dehydrogenase bioactivity is increased in the colon but not kidneys of rats given supplementary thyroxine. / Idrus, Ruszymah; Zakaria, Zaiton; Aminuddin, S.; Khalid, B. A K.

In: Experimental and Clinical Endocrinology and Diabetes, Vol. 109, No. 4, 2001, p. 227-230.

Research output: Contribution to journalArticle

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