α-glucosidase inhibitors isolated from Mimosa pudica L.

S. T. Tasnuva, U. A. Qamar, Kashif Ghafoor, F. Sahena, M. H.A. Jahurul, A. H. Rukshana, M. J. Juliana, Fahad Y. Al-Juhaimi, Jalifah Latip, K. C.A. Jalal, Md Eaqub Ali, I. S.M. Zaidul

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 28 Dec 2017

Fingerprint

Mimosa
Mimosa pudica
Glucosidases
glucosidases
enzyme inhibitors
digestive enzymes
Enzyme Inhibitors
acarbose
Acarbose
Stigmasterol
Column chromatography
stigmasterol
Bioassay
Silica Gel
Quercetin
silica gel
Fractionation
Medical problems
Biological Assay
quercetin

Keywords

  • Fabaceae
  • Mimosa pudica
  • α-glucosidase inhibitors

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

Tasnuva, S. T., Qamar, U. A., Ghafoor, K., Sahena, F., Jahurul, M. H. A., Rukshana, A. H., ... Zaidul, I. S. M. (Accepted/In press). α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research, 1-5. https://doi.org/10.1080/14786419.2017.1419224

α-glucosidase inhibitors isolated from Mimosa pudica L. / Tasnuva, S. T.; Qamar, U. A.; Ghafoor, Kashif; Sahena, F.; Jahurul, M. H.A.; Rukshana, A. H.; Juliana, M. J.; Al-Juhaimi, Fahad Y.; Latip, Jalifah; Jalal, K. C.A.; Ali, Md Eaqub; Zaidul, I. S.M.

In: Natural Product Research, 28.12.2017, p. 1-5.

Research output: Contribution to journalArticle

Tasnuva, ST, Qamar, UA, Ghafoor, K, Sahena, F, Jahurul, MHA, Rukshana, AH, Juliana, MJ, Al-Juhaimi, FY, Latip, J, Jalal, KCA, Ali, ME & Zaidul, ISM 2017, 'α-glucosidase inhibitors isolated from Mimosa pudica L.', Natural Product Research, pp. 1-5. https://doi.org/10.1080/14786419.2017.1419224
Tasnuva ST, Qamar UA, Ghafoor K, Sahena F, Jahurul MHA, Rukshana AH et al. α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research. 2017 Dec 28;1-5. https://doi.org/10.1080/14786419.2017.1419224
Tasnuva, S. T. ; Qamar, U. A. ; Ghafoor, Kashif ; Sahena, F. ; Jahurul, M. H.A. ; Rukshana, A. H. ; Juliana, M. J. ; Al-Juhaimi, Fahad Y. ; Latip, Jalifah ; Jalal, K. C.A. ; Ali, Md Eaqub ; Zaidul, I. S.M. / α-glucosidase inhibitors isolated from Mimosa pudica L. In: Natural Product Research. 2017 ; pp. 1-5.
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