• 1497 Citations
  • 20 h-Index
20042019
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Research Output 2004 2019

  • 1497 Citations
  • 20 h-Index
  • 112 Article
  • 1 Review article
2019
Open Access
Cell Movement
Fibroblasts
Cell Proliferation
Vitamin K 3
Skin
Stichopus
Cartilage
Articular Cartilage
Chondrocytes
Matrix Metalloproteinases
2018

Chondrogenesis of adipose-derived stem cells with chondrocytes in low serum towards clinical application

Hamid, A. A., Jeyabalan, S. V., Omar, A., Yasin, N. Z. H. M., Lin, W. T., Ling, L. L., Abdul Ghani, N. A., Wan Hamizan, A. K. & Kien Hui, C., 1 Oct 2018, In : Sains Malaysiana. 47, 10, p. 2369-2379 11 p.

Research output: Contribution to journalArticle

Chondrogenesis
Chondrocytes
Coculture Techniques
Stem Cells
Cell Proliferation
Hematopoietic Stem Cells
Benzene
Genes
Metabolites
Gene expression
1 Citation (Scopus)
Hep G2 Cells
Stem cells
Mesenchymal Stromal Cells
Stem Cells
Cells
2 Citations (Scopus)

Optimization of the static human osteoblast/osteoclast co-culture system

Jolly, J. J., Kok Yong, C., Farhana, M. F. N., Alias, E., Kien Hui, C., Hasan, W. N. W. & Soelaiman, I. N., 1 Mar 2018, In : Iranian Journal of Medical Sciences. 43, 2, p. 208-213 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Coculture Techniques
Osteoblasts
Staining and Labeling
Blood Cells

Piper sarmentosum as an antioxidant: A systematic review

Ismail, S. M., Kien Hui, C., Aminuddin, A. & Ugusman, A., 1 Oct 2018, In : Sains Malaysiana. 47, 10, p. 2359-2368 10 p.

Research output: Contribution to journalArticle

Piper
Antioxidants
PubMed
Databases
Pharmacology
Piper
Vascular Cell Adhesion Molecule-1
Human Umbilical Vein Endothelial Cells
Intercellular Adhesion Molecule-1
U937 Cells
1 Citation (Scopus)
Bone and Bones
Osteoporosis
Berberidaceae
Myrsinaceae
Arecaceae
2017

Acanthamoeba-mediated cytopathic effect correlates with MBP and AhLBP mRNA expression

Ng, S. L., Nordin, A., Abd. Ghafar, N., Suboh, Y., Ab Rahim, N. & Kien Hui, C., 28 Dec 2017, In : Parasites and Vectors. 10, 1, 0625.

Research output: Contribution to journalArticle

Acanthamoeba
Messenger RNA
Acanthamoeba Keratitis
Genotype
Keratitis
1 Citation (Scopus)
Tocotrienols
Omeprazole
Intercellular Signaling Peptides and Proteins
Stomach
Transforming Growth Factor alpha
5 Citations (Scopus)

Effect of alginate concentration on chondrogenesis of co-cultured human adipose-derived stem cells and nasal chondrocytes: A biological study

Ewa-Choy, Y. W., Pingguan-Murphy, B., Abdul Ghani, N. A., Jahendran, J. & Kien Hui, C., 17 Oct 2017, In : Biomaterials Research. 21, 1

Research output: Contribution to journalArticle

Chondrogenesis
Alginate
Chondrocytes
Stem cells
Nose
2 Citations (Scopus)

Piper betle L. Modulates Senescence-Associated Genes Expression in Replicative Senescent Human Diploid Fibroblasts

Durani, L. W., Khor, S. C., Tan, J. K., Kien Hui, C., Mohd Yusof, Y. A. & Makpol, S., 2017, In : BioMed Research International. 2017, 6894026.

Research output: Contribution to journalArticle

Piper betle
Fibroblasts
Diploidy
Gene expression
Gene Expression
Honey
Epithelial Cells
Keratin-3
Cornea
Cell Cycle

The Use of Engineered Bilayered Skin (MyDermTM) in the Management of Massive Skin Defect in Grade III Gustilo-Anderson Open Fracture

Mohamed Haflah, N. H., Ng, M. H., Mohd Yunus, M. H., Selvi Naicker, A., Htwe, O., Fahmi, M., Ishak, M. F., Seet, W. T., Khairoji, K. A., Maarof, M., Kien Hui, C., Shamsuddin, S. A. & Idrus, R., 1 Sep 2017, In : International Journal of Lower Extremity Wounds. 16, 3, p. 212-216 5 p.

Research output: Contribution to journalArticle

Open Fractures
Tibia
Skin
Wounds and Injuries
Tibial Arteries
1 Citation (Scopus)

Tocotrienols stimulate insulin secretion of rat pancreatic isolated islets in a dynamic culture

Chia, L. L., Jantan, I. & Kien Hui, C., 1 Jan 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 560-568 9 p.

Research output: Contribution to journalArticle

Tocotrienols
Islets of Langerhans
Insulin
Glucose
Calcium
2016
1 Citation (Scopus)

Acacia honey accelerates in vitro corneal ulcer wound healing model

Abd. Ghafar, N., Ker-Woon, C., Kien Hui, C., Mohd Yusof, Y. A. & Wan Ngah, W. Z., 29 Jul 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 259.

Research output: Contribution to journalArticle

Acacia
Corneal Ulcer
Honey
Wound Healing
Aldehyde Dehydrogenase
2 Citations (Scopus)

Assessment of tumourigenic potential in long-term cryopreserved human adipose-derived stem cells

Yong, K. W., Safwani, W. K. Z. W., Xu, F., Zhang, X., Choi, J. R., Abas, W. A. B. W., Omar, S. Z., Azmi, M. A. N., Kien Hui, C. & Pingguan-Murphy, B., 2016, (Accepted/In press) In : Journal of Tissue Engineering and Regenerative Medicine.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Stem Cells
Chromosome Aberrations
Cryoprotective Agents
4 Citations (Scopus)

Chondrogenesis of human adipose derived stem cells for future microtia repair using co-culture technique

Goh, B. S., Che Omar, S. N., Ubaidah, M. A., Saim, L., Sulaiman, S. & Kien Hui, C., 29 Nov 2016, (Accepted/In press) In : Acta Oto-Laryngologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Chondrogenesis
Culture Techniques
Coculture Techniques
Stem Cells
Chondrocytes
5 Citations (Scopus)

Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture

Chia, L. L., Jantan, I., Kien Hui, C., Lam, K. W., Rullah, K. & Aluwi, M. F. M., 30 Aug 2016, In : Frontiers in Pharmacology. 7, AUG, 291.

Research output: Contribution to journalArticle

Tocotrienols
Islets of Langerhans
Insulin
Gene Expression
Glucose
13 Citations (Scopus)

Enhanced in vitro angiogenic behaviour of human umbilical vein endothelial cells on thermally oxidized TiO 2 nanofibrous surfaces

Tan, A. W., Liau, L. L., Kien Hui, C., Ahmad, R., Akbar, S. A. & Pingguan-Murphy, B., 17 Feb 2016, In : Scientific Reports. 6, 21828.

Research output: Contribution to journalArticle

Human Umbilical Vein Endothelial Cells
Bone and Bones
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
CD31 Antigens
2 Citations (Scopus)
Corneal Keratocytes
Honey
Phenotype
Gene Expression
Immunohistochemistry
3 Citations (Scopus)
Hydrogen Peroxide
Hepatocytes
Up-Regulation
Gene Expression
Wounds and Injuries
2 Citations (Scopus)

γ-Tocotrienol prevents cell cycle arrest in aged human fibroblast cells through p16INK4a pathway

Zainuddin, A., Kien Hui, C., Tan, J. K., Jaafar, F. & Makpol, S., 14 Oct 2016, (Accepted/In press) In : Journal of Physiology and Biochemistry. p. 1-7 7 p.

Research output: Contribution to journalArticle

Tocotrienols
Fibroblasts
Cell Cycle Checkpoints
Diploidy
Cell Aging
2015
5 Citations (Scopus)
Tantalum
Chondrocytes
Fibrin
Cartilage
Rabbits
4 Citations (Scopus)

Differential osteogenic potential of human adipose-derived stem cells co-cultured with human osteoblasts on polymeric microfiber scaffolds

Rozila, I., Azari, P., Munirah, SB., Wan Safwani, W. K. Z., Gan, S. N., Nur Azurah, A. G., Jahendran, J., Pingguan-Murphy, B. & Chua, K. H., 2015, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.

Research output: Contribution to journalArticle

Osteoblasts
Stem cells
Scaffolds
Durapatite
Hydroxyapatite

Effect of Growth Factor Supplementation on the Hair Cell Specific Markers of Cells Harvested from Basilar Membrane

Ubaidah, M. A. Z., Kien Hui, C., Ami, M., Zainal, A., Saim, A., Saim, L., Yogeswaran, L. & Idrus, R., 1 Apr 2015, In : The journal of international advanced otology. 11, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

Basilar Membrane
Intercellular Signaling Peptides and Proteins
Calbindin 2
Nestin
Stem Cells
4 Citations (Scopus)

Electrospun Biopolyesters as Drug Screening Platforms for Corneal Keratocytes

Azari, P., Luan, N. S., Gan, S. N., Yahya, R., Wong, C. S., Kien Hui, C. & Pingguan-Murphy, B., 22 Nov 2015, In : International Journal of Polymeric Materials and Polymeric Biomaterials. 64, 15, p. 785-791 7 p.

Research output: Contribution to journalArticle

Polycaprolactone
Screening
Pharmaceutical Preparations
Acids
Cell proliferation
28 Citations (Scopus)

In situ normoxia enhances survival and proliferation rate of human adipose tissue-derived stromal cells without increasing the risk of tumourigenesis

Choi, J. R., Pingguan-Murphy, B., Abas, W. A. B. W., Yong, K. W., Poon, C. T., Azmi, A. N., Omar, S. Z., Kien Hui, C., Xu, F. & Safwani, W. K. Z. W., 23 Jan 2015, In : PLoS One. 10, 1, e0115034.

Research output: Contribution to journalArticle

normoxia
stromal cells
Stromal Cells
adipose tissue
Adipose Tissue
40 Citations (Scopus)

Phenotypic and Functional Characterization of Long-Term Cryopreserved Human Adipose-derived Stem Cells

Yong, K. W., Pingguan-Murphy, B., Xu, F., Abas, W. A. B. W., Choi, J. R., Omar, S. Z., Azmi, M. A. N., Kien Hui, C. & Safwani, W. K. Z. W., 15 Apr 2015, In : Scientific Reports. 5, 9596.

Research output: Contribution to journalArticle

Dimethyl Sulfoxide
Stem Cells
Cryoprotective Agents
Cryopreservation
Serum
12 Citations (Scopus)
Tocotrienols
tocotrienols
Biomarkers
lesions (animal)
biomarkers
5 Citations (Scopus)

The effects of acacia honey on in vitro corneal abrasion wound healing model

Ker-Woon, C., Abd. Ghafar, N., Kien Hui, C., Mohd Yusof, Y. A. & Ngah, W. Z. W., 18 Feb 2015, In : BMC Cell Biology. 16, 1, 53.

Research output: Contribution to journalArticle

Acacia
Honey
Wound Healing
Epithelial Cells
Wounds and Injuries
7 Citations (Scopus)

The formation of human auricular cartilage from microtic tissue: An in vivo study

Ishak, M. F. B., Goh, B. S., Kien Hui, C., Abdullah, A., Saim, L. B., Saim, A. B. & Idrus, R., 1 Oct 2015, In : International Journal of Pediatric Otorhinolaryngology. 79, 10, p. 1634-1639 6 p.

Research output: Contribution to journalArticle

Ear Cartilage
Chondrocytes
Cartilage
Staining and Labeling
Collagen Type II
2014
3 Citations (Scopus)

Allogeneic bilayered tissue-engineered skin promotes full-thickness wound healing in ovine model

Idrus, R., Rameli, M. A. B. P., Cheong, L. K., Xian, L. J., Kien Hui, C., Latiff, M. B. A. & Saim, A. B., 2014, In : Biomedical Research. 25, 2, p. 192-198 7 p.

Research output: Contribution to journalArticle

Wound Healing
Sheep
Skin
Tissue
Wounds and Injuries
10 Citations (Scopus)

Comparison of the effects between animal-derived trypsin and recombinant trypsin on human skin cells proliferation, gene and protein expression

Manira, M., Khairul Anuar, K., Seet, W. T., Ahmad Irfan, A. W., Ng, M. H., Kien Hui, C., Mohd Yunus, M. H., Aminuddin, B. S. & Idrus, R., 2014, In : Cell and Tissue Banking. 15, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

Ethylenediaminetetraacetic acid
Cell proliferation
Trypsin
Skin
Animals
4 Citations (Scopus)

Effect of acacia honey on cultured rabbit corneal keratocytes

Ker-Woon, C., Abd. Ghafar, N., Kien Hui, C. & Mohd Yusof, Y. A., 26 May 2014, In : BMC Cell Biology. 15, 1, 19.

Research output: Contribution to journalArticle

Corneal Keratocytes
Acacia
Honey
Rabbits
Wound Healing
17 Citations (Scopus)

Full-thickness skin wound healing using autologous keratinocytes and dermal fibroblasts with fibrin: Bilayered versus single-layered substitute

Idrus, R., Rameli, M. A. B. P., Low, K. C., Law, J. X., Kien Hui, C., Abdul Latiff, M. B. & Saim, A. B., 2014, In : Advances in Skin and Wound Care. 27, 4, p. 171-180 10 p.

Research output: Contribution to journalArticle

Fibrin
Keratinocytes
Wound Healing
Fibroblasts
Skin
7 Citations (Scopus)

Impact of adipogenic differentiation on stemness and osteogenic gene expression in extensive culture of human adipose-derived stem cells

Safwani, W. K. Z. W., Makpol, S., Sathapan, S. & Kien Hui, C., 2014, In : Archives of Medical Science. 10, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

Stem Cells
Gene Expression
Genes
Multipotent Stem Cells
Adipogenesis
57 Citations (Scopus)

Impact of low oxygen tension on stemness, proliferation and differentiation potential of human adipose-derived stem cells

Choi, J. R., Pingguan-Murphy, B., Wan Abas, W. A. B., Noor Azmi, M. A., Omar, S. Z., Kien Hui, C. & Wan Safwani, W. K. Z., 30 May 2014, In : Biochemical and Biophysical Research Communications. 448, 2, p. 218-224 7 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Oxygen
Cartilage
Cell Differentiation
18 Citations (Scopus)

Long-term in vitro expansion of human adipose-derived stem cells showed low risk of tumourigenicity

Wan Kamarul Zaman, W. S., Makpol, S., Sathapan, S. & Kien Hui, C., Jan 2014, In : Journal of Tissue Engineering and Regenerative Medicine. 8, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Cell culture
Telomerase
Telomere
4 Citations (Scopus)

New method for the isolation of endothelial cells from large vessels

Ataollahi, F., Pingguan-Murphy, B., Moradi, A., Bakar Wan Abas, W. A., Kien Hui, C. & Abu Osman, N. A., 2014, In : Cytotherapy. 16, 8, p. 1145-1152 8 p.

Research output: Contribution to journalArticle

Endothelial Cells
Digestion
Research Personnel
von Willebrand Factor
Collagenases
13 Citations (Scopus)

Osteogenic potential of in situ TiO2 nanowire surfaces formed by thermal oxidation of titanium alloy substrate

Tan, A. W., Ismail, R., Kien Hui, C., Ahmad, R., Akbar, S. A. & Pingguan-Murphy, B., 30 Nov 2014, In : Applied Surface Science. 320, p. 161-170 10 p.

Research output: Contribution to journalArticle

Titanium alloys
Control surfaces
Nanowires
Osteoblasts
Cell adhesion
3 Citations (Scopus)

Phenotypic characterization of culture expanded rabbit limbal corneal keratocytes

Abd. Ghafar, N., Kien Hui, C., Wan Ngah, W. Z., Che Hamzah, J., Othman, F., Abd Rahman, R. & Idrus, R., 2014, In : Cell and Tissue Banking. 15, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

Corneal Keratocytes
Aldehyde Dehydrogenase
Keratin-3
Collagen Type I
Aldehydes
6 Citations (Scopus)

Proliferation and stemness preservation of human adipose-derived stem cells by surface-modified in situ TiO2 nanofibrous surfaces

Tan, A. W., Tay, L., Kien Hui, C., Ahmad, R., Akbar, S. A. & Pingguan-Murphy, B., 21 Nov 2014, In : International Journal of Nanomedicine. 9, 1, p. 5389-5401 13 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Nanofibers
Electron Scanning Microscopy
Cell proliferation
7 Citations (Scopus)

Retropatellar fat pad-derived stem cells from older osteoarthritic patients have lesser differentiation capacity and expression of stemness genes

Kien Hui, C., Zaman Wan Safwani, W. K., A. Hamid, A., Shuhup, S. K., Mohd Haflah, N. H. & Mohamad Yahaya, N. H., 2014, In : Cytotherapy. 16, 5, p. 599-611 13 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Adipose Tissue
Stem Cells
Gene Expression
Cartilage
18 Citations (Scopus)

Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells

Ugusman, A., Zakaria, Z., Kien Hui, C., Megat Mohd Nordin, N. A. & Abdullah Mahdy, Z., 2014, In : Scientific World Journal. 2014, 169370.

Research output: Contribution to journalArticle

Rutin
Endothelial cells
Human Umbilical Vein Endothelial Cells
nitric oxide
Nitric Oxide
3 Citations (Scopus)

The use of autologous fibrin as a scaffold for cultivating autologous conjunctiva in the treatment of conjunctival defect

Mohd Khialdin, S., Abd. Ghafar, N., Hairul Nizam, M. H., Ropilah, A. R., Faridah, H. A., Kien Hui, C., Idrus, R. & Che Hamzah, J., 6 Nov 2014, In : Cell and Tissue Banking. 15, 4, p. 619-626 8 p.

Research output: Contribution to journalArticle

Conjunctiva
Fibrin
Scaffolds
Amnion
Membranes
7 Citations (Scopus)

Vitamin E: A potential therapy for gastric mucosal injury

Yusof, K., Mohd Saad, Q., Kien Hui, C. & Mohd Fahami, N. A., 1 Dec 2014, In : Pharmaceutical Biology. 52, 12, p. 1591-1597 7 p.

Research output: Contribution to journalArticle

Vitamin E
Stomach
Tocotrienols
Tocopherols
Wounds and Injuries
2013
10 Citations (Scopus)

Alteration of gene expression levels during osteogenic induction of human adipose derived stem cells in long-term culture

Safwani, W. K. Z. W., Makpol, S., Sathapan, S. & Kien Hui, C., Jun 2013, In : Cell and Tissue Banking. 14, 2, p. 289-301 13 p.

Research output: Contribution to journalArticle

Stem cells
Cell culture
Gene expression
Stem Cells
Gene Expression
25 Citations (Scopus)

Edible Bird's nest extract as a chondro-protective agent for human chondrocytes isolated from osteoarthritic knee: In vitro study

Kien Hui, C., Lee, T. H., Nagandran, K., Mohamad Yahaya, N. H., Lee, C. T., Tjih, E. T. T. & Abdul Aziz, R., 22 Jan 2013, In : BMC Complementary and Alternative Medicine. 13, 19.

Research output: Contribution to journalArticle

Protective Agents
Chondrocytes
Birds
Knee
Joints