• 414 Citations
  • 10 h-Index
20062019
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Research Output 2006 2019

  • 414 Citations
  • 10 h-Index
  • 38 Article
  • 1 Review article
2019

Cytotoxic activity of Tinospora crispa crude extracts (stem) against k562 human leukemia cells

Awang, N., Ruzali, H. I., Mohamad, R., Kok Meng, C. & Nurul Farahana, K., 1 Jan 2019, In : OnLine Journal of Biological Sciences. 19, 2, p. 117-123 7 p.

Research output: Contribution to journalArticle

Tinospora
Complex Mixtures
leukemia
Methylene Chloride
Leukemia
2018
2 Citations (Scopus)

Dendritic cells pulsed with generated tumor cell lysate from Phyllanthus amarus Schum. & Thonn. induces anti-tumor immune response

Mohamed, S. I. A., Jantan, I., Nafiah, M. A., Seyed, M. A. & Kok Meng, C., 6 Aug 2018, In : BMC Complementary and Alternative Medicine. 18, 1, 232.

Research output: Contribution to journalArticle

Phyllanthus
Dendritic Cells
Neoplasms
Interleukin-12
Interleukin-6
Hematopoietic Stem Cells
Benzene
Genes
Metabolites
Gene expression

Neuroprotective effects of ocimum basilicum extract against hydrogen peroxide-induced oxidative stress in SK-N-SH neuroblastoma cells

Mohd-Zahid, M. H., Jalil, J., Kok Meng, C. & Azmi, N., 1 Jan 2018, In : Sains Malaysiana. 47, 9, p. 2129-2139 11 p.

Research output: Contribution to journalArticle

neuroprotective effect
Ocimum basilicum
hydrogen peroxide
oxidative stress
pretreatment
2 Citations (Scopus)

Water extract of Clinacanthus nutans leaves exhibits in vitro, ex vivo and in vivo anti-angiogenic activities in endothelial cell via suppression of cell proliferation

Ng, C. T., Fong, L. Y., Tan, J. J., Rajab, N. F., Abas, F., Shaari, K., Kok Meng, C., Juliana, F. & Yong, Y. K., 6 Jul 2018, In : BMC Complementary and Alternative Medicine. 18, 1, 210.

Research output: Contribution to journalArticle

Endothelial Cells
Cell Proliferation
Water
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
2017
3 Citations (Scopus)
Carnosine
Genomic Instability
Zinc
Anti-Inflammatory Agents
Antioxidants
28 Citations (Scopus)

Source apportionment and health risk assessment among specific age groups during haze and non-haze episodes in Kuala Lumpur, Malaysia

Sulong, N. A., Latif, M. T., Khan, F., Amil, N., Ashfold, M. J., A Wahab, M. I., Kok Meng, C. & Sahani, M., 1 Dec 2017, In : Science of the Total Environment. 601-602, p. 556-570 15 p.

Research output: Contribution to journalArticle

Health risks
haze
Aerosols
Risk assessment
health risk
1 Citation (Scopus)
Carnosine
Heme Oxygenase-1
Macrophages
Lipopolysaccharides
Zinc
2016
9 Citations (Scopus)
HCT116 Cells
Acetone
Colorectal Neoplasms
Cell Line
Fluorescein-5-isothiocyanate

Cytotoxicity and genotoxicity assessments of batik industrial wastewater on V79 cells

Awang, N., Ehlam, S. N. F. & Kok Meng, C., 2016, In : Journal of Chemical and Pharmaceutical Sciences. 9, 4, p. 3221-3226 6 p.

Research output: Contribution to journalArticle

Cytotoxicity
Waste Water
Wastewater
Inhibitory Concentration 50
Assays
2 Citations (Scopus)
Hazardous Substances
Labeling
2 Citations (Scopus)
DNA Damage
Methanol
Colorectal Neoplasms
Oxidative Stress
Apoptosis
5 Citations (Scopus)

Human health risk assessment of heavy metals in shellfish from Kudat, Sabah

Sharif @ Mohd Sharif, R., Chong, E. & Kok Meng, C., 1 Jan 2016, In : Malaysian Journal of Nutrition. 22, 2, p. 301-305 5 p.

Research output: Contribution to journalArticle

Shellfish
Malaysia
Borneo
shellfish
Heavy Metals
14 Citations (Scopus)
Phyllanthus
Phagocytes
Inhibitory Concentration 50
Nitric Oxide
Lymphocytes
Cytotoxicity
leukemia
Toxicity
cytotoxicity
Leukemia
7 Citations (Scopus)
HL-60 Cells
Nuclear magnetic resonance spectroscopy
nuclear magnetic resonance
Magnetic Resonance Spectroscopy
spectroscopy

Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells

Fasihi Mohd Aluwi, M. F., Rullah, K., Huan, T. H., Kok Meng, C., Jie, T. S., Wei, L. S., Mansor, A. H., Mohd. Yamin, B. & Lam, K. W., 2016, In : RSC Advances. 6, 76, p. 72177-72184 8 p.

Research output: Contribution to journalArticle

Melanin
Oxadiazoles
Monophenol Monooxygenase
Skin
Melanins
8 Citations (Scopus)
Carnosine
Macrophages
Mitogen-Activated Protein Kinases
Lipopolysaccharides
Zinc
2015
9 Citations (Scopus)

Antioxidant activity of red algae Kappaphycus alvarezii and Kappaphycus striatum

Farah Diyana, A., Abdullah, A., Zainal Ariffin, S. H. & Kok Meng, C., 2015, In : International Food Research Journal. 22, 5, p. 1977-1984 8 p.

Research output: Contribution to journalArticle

Kappaphycus
Kappaphycus alvarezii
Rhodophyta
Antioxidants
antioxidant activity

Cytotoxicity and genotoxicity assessments of batik industrial wastewater on V79 cells

Awang, N., Ehlam, S. N. F., Kok Meng, C. & Nurul Farahana, K., 1 Sep 2015, In : Toxicology International. 22, 3, p. 76-82 7 p.

Research output: Contribution to journalArticle

Cytotoxicity
Waste Water
Wastewater
Inhibitory Concentration 50
Assays
5 Citations (Scopus)

Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells

Chow, P. W., Abd Hamid, Z., Kok Meng, C., Inayat-Hussain, S. H. & Rajab, N. F., 1 Apr 2015, In : Toxicology and Applied Pharmacology. 284, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

Cytotoxicity
Hematopoietic Stem Cells
Stem Cells
Benzene
Stem cells
Jurkat Cells
Caspase 3
Toxicity
Reactive Oxygen Species
Chemical activation
2014
91 Citations (Scopus)

Concentration and source identification of polycyclic aromatic hydrocarbons (PAHs) in PM10 of urban, industrial and semi-urban areas in Malaysia

Jamhari, A. A., Sahani, M., Latif, M. T., Kok Meng, C., Tan, H. S., Khan, F. & Mohd Tahir, N., Apr 2014, In : Atmospheric Environment. 86, p. 16-27 12 p.

Research output: Contribution to journalArticle

PAH
urban area
health risk
fluoranthene
traffic emission
Kappaphycus
Kappaphycus alvarezii
Seaweed
Hep G2 Cells
seaweed
7 Citations (Scopus)
Cell death
Cytotoxicity
cytotoxicity
cell death
Cell Death
2 Citations (Scopus)

Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells.

Yen, H. K., Fauzi, A. R., Din, L. B., McKelvey-Martin, V. J., Meng, C. K., Inayat-Hussain, S. H. & Rajab, N. F., 2014, In : BMC Complementary and Alternative Medicine. 14

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Apoptosis
Fluorescein-5-isothiocyanate
Annexin A5
Cell Line
2013
16 Citations (Scopus)
Hydroxamic Acids
X-Ray Diffraction
Ligands
Derivatives
X ray diffraction

Erratum: Design, synthesis, in vitro cytotoxicity evaluation and structure-activity relationship of Goniothalamin analogs (Archives of Pharmacal Research DOI 10.1007/s12272-013-0099-1)

Mohideen, M., Zulkepli, S., Nik-Salleh, N. S., Leong, L. H., Kok Meng, C., Inayat-Hussain, S. H., Zulkefeli, M., Weber, J. F. F. & Rahman, A. F. M. M., Jul 2013, In : Archives of Pharmacal Research. 36, 7, p. 918 1 p.

Research output: Contribution to journalArticle

Cytotoxicity
goniothalamin
13 Citations (Scopus)
crystal structure
leukemia
crystals
cytotoxicity
cell lines
1 Citation (Scopus)

Tear proteomics in young Malays with dry eyes

Mohd. Ali, B., Nguan, D. K. C., Ishak, B. & Kok Meng, C., Dec 2013, In : International Medical Journal Malaysia. 12, 2, p. 39-43 5 p.

Research output: Contribution to journalArticle

Tears
Proteomics
Lactoferrin
Muramidase
Serum Albumin
2012
10 Citations (Scopus)

3,5-Dibenzyloxy-4'-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells

Roslie, H., Kok Meng, C., Rajab, N. F., Velu, S. S., Kadir, S. A. I. A. S. A., Bunyamin, I., Weber, J. F. F., Thomas, N. F., Majeed, A. B. A., Myatt, G. & Inayat-Hussain, S. H., Feb 2012, In : Journal of Toxicological Sciences. 37, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Caspase 9
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Stilbenes
Chemical activation
Apoptosis
7 Citations (Scopus)

Protection of hydroquinone-induced apoptosis by downregulation of Fau is mediated by NQO1

Siew, E. L., Kok Meng, C., Williams, G. T., Ross, D. & Inayat-Hussain, S. H., 15 Oct 2012, In : Free Radical Biology and Medicine. 53, 8, p. 1616-1624 9 p.

Research output: Contribution to journalArticle

Down-Regulation
Apoptosis
Benzene
Genes
DNA
7 Citations (Scopus)

The pyranoxanthone inophyllin A induces oxidative stress mediated-apoptosis in Jurkat T lymphoblastic leukemia cells

Kok Meng, C., Hamzah, R., Rahaman, A. A., Jong, V. Y. M., Khong, H. Y., Rajab, N. F., Ee, G. C. L. & Inayat-Hussain, S. H., Aug 2012, In : Food and Chemical Toxicology. 50, 8, p. 2916-2922 7 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
lymphocytic leukemia
Oxidative stress
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Oxidative Stress
2010
9 Citations (Scopus)

Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications

Kee, C. H., Ariffin, A., Awang, K., Takeya, K., Morita, H., Hussain, S. I., Kok Meng, C., Wood, P. J., Threadgill, M. D., Lim, C. G., Ng, S., Weber, J. F. F. & Thomas, N. F., 21 Dec 2010, In : Organic and Biomolecular Chemistry. 8, 24, p. 5646-5660 15 p.

Research output: Contribution to journalArticle

Stilbenes
stilbene
Toxicology
Derivatives
synthesis
44 Citations (Scopus)

Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells

Inayat-Hussain, S. H., Kok Meng, C., Rajab, N. F., Din, L. B., Chow, S. C., Kizilors, A., Farzaneh, F. & Williams, G. T., 1 Mar 2010, In : Toxicology Letters. 193, 1, p. 108-114 7 p.

Research output: Contribution to journalArticle

Caspase 2
Oxidative stress
Jurkat Cells
T-cells
DNA Damage
29 Citations (Scopus)

Goniothalamin induces coronary artery smooth muscle cells apoptosis: The p53-dependent caspase-2 activation pathway

Kok Meng, C., Rajab, N. F., Siegel, D., Din, L. B., Ross, D. & Inayat-Hussain, S. H., 4 Feb 2010, In : Toxicological Sciences. 116, 2, p. 533-548 16 p.

Research output: Contribution to journalArticle

Caspase 2
Smooth Muscle Myocytes
Muscle
Coronary Vessels
Chemical activation
5 Citations (Scopus)

Modulation of the benzene metabolite hydroquinone induced toxicity: Evidence for an important role of fau

Inayat-Hussain, S. H., Ibrahim, H. A., Siew, E. L., Rajab, N. F., Kok Meng, C., Williams, G. T. & Ross, D., Mar 2010, In : Chemico-Biological Interactions. 184, 1-2, p. 310-312 3 p.

Research output: Contribution to journalArticle

Hydroquinones
Ribosomal Proteins
Benzene
Tumor Cell Line
Cell Survival
2009
15 Citations (Scopus)

RACK-1 overexpression protects against goniothalamin-induced cell death

Inayat-Hussain, S. H., Wong, L. T., Kok Meng, C., Rajab, N. F., Din, L. B., Harun, R., Kizilors, A., Saxena, N., Mourtada-Maarabouni, M., Farzaneh, F. & Williams, G. T., 15 Dec 2009, In : Toxicology Letters. 191, 2-3, p. 118-122 5 p.

Research output: Contribution to journalArticle

Cell death
Cell Death
T-cells
Cytotoxicity
Assays
2006
61 Citations (Scopus)

Goniothalamin induces apoptosis in vascular smooth muscle cells

Kok Meng, C., Rajab, N. F., Ishak, M. H. A., Ali, A. M., Yusoff, K., Din, L. B. & Inayat-Hussain, S. H., 1 Feb 2006, In : Chemico-Biological Interactions. 159, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cells
Apoptosis