• 838 Citations
  • 11 h-Index
20092019
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Research Output 2009 2019

  • 838 Citations
  • 11 h-Index
  • 16 Article
  • 2 Comment/debate
  • 2 Review article
2019
Open Access
Zona Fasciculata
Aldosterone
Adenoma
Cytochrome P-450 CYP11B2
Mutation
2018
1 Citation (Scopus)

Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension

Azam, A. B. & Elena Aisha, A., 1 Jan 2018, In : International Journal of Endocrinology. 2018, 7259704.

Research output: Contribution to journalReview article

Genome-Wide Association Study
Single Nucleotide Polymorphism
Hypertension
Genotyping Techniques
Metagenomics
2017
17 Citations (Scopus)

Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation

Tan, G. C., Negro, G., Pinggera, A., Laim, N. M. S. T., Rose, I. M., Ceral, J., Ryska, A., Chin, L. K., Kamaruddin, N. A., Mohd Mokhtar, N., A. Jamal, A. R., Sukor, N., Solar, M., Striessnig, J., Brown, M. J. & Elena Aisha, A., 1 Jul 2017, In : Hypertension. 70, 1, p. 129-136 8 p.

Research output: Contribution to journalArticle

Aldosterone
Adenoma
Genotype
Mutation
Zona Fasciculata
2016

Effect of somatic CTNNB1 mutations on adrenocortical cell de-differentiation in adenoma presenting in early pregnancy or menopause

Teo, A. E. D., Garg, S., Haris Shaikh, L., Zhou, J., Karet Frankl, F. E., Gurnell, M., Happerfield, L., Marker, A., Bienz, M., Elena Aisha, A. & Brown, M. J., 1 Jun 2016, In : Annales d'Endocrinologie. 77, 2, p. 161-162 2 p.

Research output: Contribution to journalArticle

Menopause
Adenoma
Cell Differentiation
Zona Glomerulosa
Pregnancy
11 Citations (Scopus)

Novel genetic determinants of adrenal aldosterone regulation

Elena Aisha, A. & Brown, M. J., 1 Jun 2016, In : Current Opinion in Endocrinology, Diabetes and Obesity. 23, 3, p. 209-217 9 p.

Research output: Contribution to journalReview article

Aldosterone
Zona Glomerulosa
Hyperaldosteronism
Mutation
Adenoma
17 Citations (Scopus)

Regulation of aldosterone secretion by Ca v 1.3

Xie, C. B., Haris Shaikh, L., Garg, S., Tanriver, G., Teo, A. E. D., Zhou, J., Maniero, C., Zhao, W., Kang, S., Silverman, R. B., Elena Aisha, A. & Brown, M. J., 21 Apr 2016, In : Scientific Reports. 6, 24697.

Research output: Contribution to journalArticle

Aldosterone
Adenoma
Zona Glomerulosa
L-Type Calcium Channels
Nifedipine
9 Citations (Scopus)

Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues

Zhou, J., Lam, B., Neogi, S. G., Yeo, G. S. H., Elena Aisha, A. & Brown, M. J., 1 Dec 2016, In : Hypertension. 68, 6, p. 1424-1431 8 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Zona Glomerulosa
Aldosterone
Adenoma
Zona Fasciculata
2015
13 Citations (Scopus)

DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion

Zhou, J., Shaikh, L. H., Neogi, S. G., Mcfarlane, I., Zhao, W., Figg, N., Brighton, C. A., Maniero, C., Teo, A. E. D., Elena Aisha, A. & Brown, M. J., 21 May 2015, In : Hypertension. 65, 5, p. 1103-1110 8 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Transforming Growth Factors
Aldosterone
Genes
Adenoma
15 Citations (Scopus)

LGR5 activates noncanonical Wnt signaling and inhibits aldosterone production in the human adrenal

Shaikh, L. H., Zhou, J., Teo, A. E. D., Garg, S., Neogi, S. G., Figg, N., Yeo, G. S., Yu, H., Maguire, J. J., Zhao, W., Bennett, M. R., Elena Aisha, A., Davenport, A. P., McKenzie, G. & Brown, M. J., 1 Jun 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 6, p. E836-E844

Research output: Contribution to journalArticle

Zona Glomerulosa
Aldosterone
Genes
Adenoma
Zona Fasciculata
60 Citations (Scopus)

Pregnancy, primary aldosteronism, and adrenal CTNNB1 mutations

Teo, A. E. D., Garg, S., Shaikh, L. H., Zhou, J., Frankl, F. E. K., Gurnell, M., Happerfield, L., Marker, A., Bienz, M., Elena Aisha, A. & Brown, M. J., 8 Oct 2015, In : New England Journal of Medicine. 373, 15, p. 1429-1436 8 p.

Research output: Contribution to journalArticle

Hyperaldosteronism
Adenoma
Aldosterone
Pregnancy
Mutation
2014
69 Citations (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Elena Aisha, A., Tops, B., Deinum, J. & Küsters, B., 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes

Erratum: Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-production adenoma (J Hypertens (2012) 30 (1827-1833))

Murthy, M., Elena Aisha, A., Brown, M. J. & O'Shaughnessy, K. M., 2014, In : Journal of Hypertension. 32, 4, p. 948 1 p.

Research output: Contribution to journalComment/debate

Aldosterone
Adenoma
Mutation
2013
257 Citations (Scopus)

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

Elena Aisha, A., Poulsen, H., Tuluc, P., Zhou, J., Clausen, M. V., Lieb, A., Maniero, C., Garg, S., Bochukova, E. G., Zhao, W., Shaikh, L. H., Brighton, C. A., Teo, A. E. D., Davenport, A. P., Dekkers, T., Tops, B., Küsters, B., Ceral, J., Yeo, G. S. H., Neogi, S. G. & 13 others, McFarlane, I., Rosenfeld, N., Marass, F., Hadfield, J., Margas, W., Chaggar, K., Solar, M., Deinum, J., Dolphin, A. C., Farooqi, I. S., Striessnig, J., Nissen, P. & Brown, M. J., Sep 2013, In : Nature Genetics. 45, 9, p. 1055-1060 6 p.

Research output: Contribution to journalArticle

Aldosterone
Adenoma
Hypertension
Mutation
Zona Glomerulosa
2012
39 Citations (Scopus)

Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma

Murthy, M., Elena Aisha, A., Brown, M. J. & O'Shaughnessy, K. M., Sep 2012, In : Journal of Hypertension. 30, 9, p. 1827-1833 7 p.

Research output: Contribution to journalArticle

Aldosterone
Adenoma
Mutation
Oocytes
Inwardly Rectifying Potassium Channel
93 Citations (Scopus)

Evaluation of the sensitivity and specificity of 11C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

Burton, T. J., Mackenzie, I. S., Balan, K., Koo, B., Bird, N., Soloviev, D. V., Elena Aisha, A., Aigbirhio, F., Gurnell, M. & Brown, M. J., Jan 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

metomidate
Adrenocortical Adenoma
Positron emission tomography
Aldosterone
Tomography
113 Citations (Scopus)

Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors

Elena Aisha, A., Lam, B. Y. H., Newhouse, S. J., Zhou, J., Kuc, R. E., Clarke, J., Happerfield, L., Marker, A., Hoffman, G. J. & Brown, M. J., May 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 5

Research output: Contribution to journalArticle

Zona Fasciculata
Zona Glomerulosa
Microarrays
Aldosterone
Adenoma
108 Citations (Scopus)

Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas

Elena Aisha, A., Murthy, M., Stowasser, M., Gordon, R., Kowalski, B., Xu, S., Brown, M. J. & O'Shaughnessy, K. M., Mar 2012, In : Hypertension. 59, 3, p. 587-591 5 p.

Research output: Contribution to journalArticle

Aldosterone
Adenoma
Mutation
Hyperaldosteronism
Germ-Line Mutation
2011
6 Citations (Scopus)
Pheochromocytoma
Aldosterone
Hydrocortisone
Glucocorticoid Receptors
Angiotensin II
2009
Epithelial Sodium Channels
Aldosterone
Pharmacology
corrigendum
10 Citations (Scopus)

Expression of the epithelial Na+ channel and other components of an aldosterone response pathway in human adrenocortical cells

Burton, T. J., Cope, G., Wang, J., Sim, J. C., Elena Aisha, A., O'Shaughnessy, K. M. & Brown, M. J., 24 Jun 2009, In : European Journal of Pharmacology. 613, 1-3, p. 176-181 6 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Aldosterone
Adrenal Cortex
Western Blotting
11-beta-Hydroxysteroid Dehydrogenases